Coronary Artery-Bypass-Graft Surgery Increases the Plasma Concentration of Exosomes Carrying a Cargo of Cardiac MicroRNAs: An Example of Exosome Trafficking Out of the Human Heart with Potential for Cardiac Biomarker Discovery

Costanza Emanueli; Andrew I. U. Shearn; Abas Laftah; Francesca Fiorentino; Barnaby C. Reeves; Cristina Beltrami; Andrew Mumford; Aled Clayton; Mark Gurney; Saran Shantikumar; Gianni D. Angelini

doi:10.1371/journal.pone.0154274

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Peer-reviewed

Research Article

Coronary Artery-Bypass-Graft Surgery Increases the Plasma Concentration of Exosomes Carrying a Cargo of Cardiac MicroRNAs: An Example of Exosome Trafficking Out of the Human Heart with Potential for Cardiac Biomarker Discovery

Costanza Emanueli ,

* E-mail: Costanza.Emanueli@bristol.ac.uk

Affiliations Bristol Heart Institute, University of Bristol, Bristol, United Kingdom, National Heart and Lung Institute, Imperial College London, London, United Kingdom
⨯
Andrew I. U. Shearn ,

Contributed equally to this work with: Andrew I. U. Shearn, Abas Laftah

Affiliation Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
⨯
Abas Laftah ,

Contributed equally to this work with: Andrew I. U. Shearn, Abas Laftah

Affiliation National Heart and Lung Institute, Imperial College London, London, United Kingdom
⨯
Francesca Fiorentino,

Affiliation National Heart and Lung Institute, Imperial College London, London, United Kingdom
⨯
Barnaby C. Reeves,

Affiliation Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
⨯
Cristina Beltrami,

Affiliation Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
⨯
Andrew Mumford,

Affiliation Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
⨯
Aled Clayton,

Affiliation Institute of Cancer & Genetics, University of Cardiff, Cardiff, United Kingdom
⨯
Mark Gurney,

Affiliation Institute of Cancer & Genetics, University of Cardiff, Cardiff, United Kingdom
⨯
Saran Shantikumar,

Affiliation Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
⨯
Gianni D. Angelini

Affiliations Bristol Heart Institute, University of Bristol, Bristol, United Kingdom, National Heart and Lung Institute, Imperial College London, London, United Kingdom
⨯

Coronary Artery-Bypass-Graft Surgery Increases the Plasma Concentration of Exosomes Carrying a Cargo of Cardiac MicroRNAs: An Example of Exosome Trafficking Out of the Human Heart with Potential for Cardiac Biomarker Discovery

Costanza Emanueli,
Andrew I. U. Shearn,
Abas Laftah,
Francesca Fiorentino,
Barnaby C. Reeves,
Cristina Beltrami,
Andrew Mumford,
Aled Clayton,
Mark Gurney,
Saran Shantikumar

Published: April 29, 2016
https://doi.org/10.1371/journal.pone.0154274

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Coronary artery bypass grafting
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