Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome

Danuza Rossi; Natalia M. Barbosa; Fabio C. Galvão; Paulo E. G. Boldrin; John W. B. Hershey; Cleslei F. Zanelli; Christopher S. Fraser; Sandro R. Valentini

doi:10.1371/journal.pone.0154205

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Peer-reviewed

Research Article

Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome

Danuza Rossi ,

Contributed equally to this work with: Danuza Rossi, Natalia M. Barbosa

Affiliations School of Pharmaceutical Sciences, UNESP - Univ Estadual Paulista, Department of Biological Sciences, Araraquara, SP, Brazil, 14801, Department of Molecular and Cellular Biology, University of California Davis, Davis, CA, United States of America, 95616
⨯
Natalia M. Barbosa ,

Contributed equally to this work with: Danuza Rossi, Natalia M. Barbosa

Affiliation School of Pharmaceutical Sciences, UNESP - Univ Estadual Paulista, Department of Biological Sciences, Araraquara, SP, Brazil, 14801
⨯
Fabio C. Galvão,

Affiliation School of Pharmaceutical Sciences, UNESP - Univ Estadual Paulista, Department of Biological Sciences, Araraquara, SP, Brazil, 14801
⨯
Paulo E. G. Boldrin,

Affiliation School of Pharmaceutical Sciences, UNESP - Univ Estadual Paulista, Department of Biological Sciences, Araraquara, SP, Brazil, 14801
⨯
John W. B. Hershey,

Affiliation Department of Molecular and Cellular Biology, University of California Davis, Davis, CA, United States of America, 95616
⨯
Cleslei F. Zanelli ,

¶‡ These authors also contributed equally to this work.

Affiliation School of Pharmaceutical Sciences, UNESP - Univ Estadual Paulista, Department of Biological Sciences, Araraquara, SP, Brazil, 14801
⨯
Christopher S. Fraser,

Affiliation Department of Molecular and Cellular Biology, University of California Davis, Davis, CA, United States of America, 95616
⨯
Sandro R. Valentini

* E-mail: valentsr@fcfar.unesp.br

¶‡ These authors also contributed equally to this work.

Affiliation School of Pharmaceutical Sciences, UNESP - Univ Estadual Paulista, Department of Biological Sciences, Araraquara, SP, Brazil, 14801
⨯

Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome

Danuza Rossi,
Natalia M. Barbosa,
Fabio C. Galvão,
Paulo E. G. Boldrin,
John W. B. Hershey,
Cleslei F. Zanelli,
Christopher S. Fraser,
Sandro R. Valentini

Published: April 26, 2016
https://doi.org/10.1371/journal.pone.0154205

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Ribosomes
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Yeast
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Polyribosomes
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Anisotropy
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Elongation factors
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Protein translation
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Protein synthesis
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Transfer RNA
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