Antidepressant Efficacy of Adjunctive Aerobic Activity and Associated Biomarkers in Major Depression: A 4-Week, Randomized, Single-Blind, Controlled Clinical Trial

• Cristiana Carvalho Siqueira,

  Affiliation Laboratory of Neuroscience LIM-27, Institute and Department of Psychiatry, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil

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• Leandro L. Valiengo,

  Affiliation Laboratory of Neuroscience LIM-27, Institute and Department of Psychiatry, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil

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• André F. Carvalho,

  Affiliation Department of Clinical Medicine and Translational Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil

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• Paulo Roberto Santos-Silva,

  Affiliation Laboratory of Movement Studies, University of Sao Paulo School of Medicine Hospital das Clínicas, Sao Paulo, Sao Paulo, Brazil

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• Giovani Missio,

  Affiliation Mood Disorders Unit (GRUDA), Institute and Department of Psychiatry, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil

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• Rafael T. de Sousa,

  Affiliations Laboratory of Neuroscience LIM-27, Institute and Department of Psychiatry, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil, Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health (NIMH), Bethesda, Maryland, United States of America

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• Georgia Di Natale,

  Affiliation Laboratory of Neuroscience LIM-27, Institute and Department of Psychiatry, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil

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• Wagner F. Gattaz,

  Affiliations Laboratory of Neuroscience LIM-27, Institute and Department of Psychiatry, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil, Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil

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• Ricardo Alberto Moreno,

  Affiliation Mood Disorders Unit (GRUDA), Institute and Department of Psychiatry, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil

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• Rodrigo Machado-Vieira

  * E-mail: machadovieirar@gmail.com; machadovieirar@mail.nih.gov

  Affiliations Laboratory of Neuroscience LIM-27, Institute and Department of Psychiatry, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil, Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health (NIMH), Bethesda, Maryland, United States of America, Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil

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