X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain

Firas Fadel; Yuguang Zhao; Alexandra Cousido-Siah; Francesc X. Ruiz; André Mitschler; Alberto Podjarny

doi:10.1371/journal.pone.0154190

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Peer-reviewed

Research Article

X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain

Firas Fadel ,

* E-mail: firasfadel1@gmail.com (FF); podjarny@igbmc.fr (AP)

Current address: Laboratoire d’Ingénierie des Systèmes Macromoléculaires, UMR7255 CNRS - Aix Marseille University, Marseille, France and Architecture et Fonction des Macromolécules Biologiques – UMR7257 CNRS – Aix-Marseille University – Case 932, Marseille, France

Affiliation Department of Integrative Biology, Institute of Genetics and Molecular and Cellular Biology (IGBMC), CNRS UMR 7104, INSERM U 964, Université de Strasbourg, Illkirch, France
⨯
Yuguang Zhao,

Affiliation Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford, United Kingdom
⨯
Alexandra Cousido-Siah,

Affiliation Department of Integrative Biology, Institute of Genetics and Molecular and Cellular Biology (IGBMC), CNRS UMR 7104, INSERM U 964, Université de Strasbourg, Illkirch, France
⨯
Francesc X. Ruiz,

Current address: Center for Advanced Biotechnology and Medicine, Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, United States of America

Affiliation Department of Integrative Biology, Institute of Genetics and Molecular and Cellular Biology (IGBMC), CNRS UMR 7104, INSERM U 964, Université de Strasbourg, Illkirch, France
⨯
André Mitschler,

Affiliation Department of Integrative Biology, Institute of Genetics and Molecular and Cellular Biology (IGBMC), CNRS UMR 7104, INSERM U 964, Université de Strasbourg, Illkirch, France
⨯
Alberto Podjarny

* E-mail: firasfadel1@gmail.com (FF); podjarny@igbmc.fr (AP)

Affiliation Department of Integrative Biology, Institute of Genetics and Molecular and Cellular Biology (IGBMC), CNRS UMR 7104, INSERM U 964, Université de Strasbourg, Illkirch, France
⨯

X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain

Firas Fadel,
Yuguang Zhao,
Alexandra Cousido-Siah,
Francesc X. Ruiz,
André Mitschler,
Alberto Podjarny

Published: April 25, 2016
https://doi.org/10.1371/journal.pone.0154190

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Crystal structure
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Chitin
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