Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase

Jerome Deval; Amy Fung; Sarah K. Stevens; Paul C. Jordan; Tatiana Gromova; Joshua S. Taylor; Jin Hong; Jia Meng; Guangyi Wang; Natalia Dyatkina; Marija Prhavc; Julian A. Symons; Leo Beigelman

doi:10.1371/journal.pone.0154097

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Open Access

Peer-reviewed

Research Article

Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase

Jerome Deval ,

* E-mail: jdeval@its.jnj.com

Affiliation Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California, United States of America

http://orcid.org/0000-0001-8369-907X

⨯
Amy Fung,

Affiliation Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California, United States of America
⨯
Sarah K. Stevens,

Affiliation Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California, United States of America
⨯
Paul C. Jordan,

Affiliation Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California, United States of America
⨯
Tatiana Gromova,

Affiliation Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California, United States of America
⨯
Joshua S. Taylor,

Affiliation Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California, United States of America
⨯
Jin Hong,

Affiliation Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California, United States of America
⨯
Jia Meng,

Affiliation Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California, United States of America
⨯
Guangyi Wang,

Affiliation Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California, United States of America
⨯
Natalia Dyatkina,

Affiliation Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California, United States of America
⨯
Marija Prhavc,

Affiliation Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California, United States of America
⨯
Julian A. Symons,

Affiliation Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California, United States of America
⨯
Leo Beigelman

Affiliation Alios BioPharma, Inc., part of the Janssen Pharmaceutical Companies, South San Francisco, California, United States of America
⨯

Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase

Jerome Deval,
Amy Fung,
Sarah K. Stevens,
Paul C. Jordan,
Tatiana Gromova,
Joshua S. Taylor,
Jin Hong,
Jia Meng,
Guangyi Wang,
Natalia Dyatkina

Published: May 10, 2016
https://doi.org/10.1371/journal.pone.0154097

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