A Regional Reduction in Ito and IKACh in the Murine Posterior Left Atrial Myocardium Is Associated with Action Potential Prolongation and Increased Ectopic Activity

Andrew P. Holmes; Ting Y. Yu; Samantha Tull; Fahima Syeda; Stefan M. Kuhlmann; Sian-Marie O’Brien; Pushpa Patel; Keith L. Brain; Davor Pavlovic; Nigel A. Brown; Larissa Fabritz; Paulus Kirchhof

doi:10.1371/journal.pone.0154077

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Open Access

Peer-reviewed

Research Article

A Regional Reduction in I_to and I_KACh in the Murine Posterior Left Atrial Myocardium Is Associated with Action Potential Prolongation and Increased Ectopic Activity

Andrew P. Holmes ,

Contributed equally to this work with: Andrew P. Holmes, Ting Y. Yu

Affiliation Institute of Cardiovascular Science, University of Birmingham, Birmingham, United Kingdom
⨯
Ting Y. Yu ,

Contributed equally to this work with: Andrew P. Holmes, Ting Y. Yu

Affiliations Institute of Cardiovascular Science, University of Birmingham, Birmingham, United Kingdom, Physical Sciences of Imaging in the Biomedical Sciences, School of Chemistry, College of Engineering Physical Sciences, University of Birmingham, Birmingham, United Kingdom
⨯
Samantha Tull,

Affiliation Institute of Cardiovascular Science, University of Birmingham, Birmingham, United Kingdom
⨯
Fahima Syeda,

Affiliation Institute of Cardiovascular Science, University of Birmingham, Birmingham, United Kingdom
⨯
Stefan M. Kuhlmann,

Affiliation Institute of Cardiovascular Science, University of Birmingham, Birmingham, United Kingdom
⨯
Sian-Marie O’Brien,

Affiliation Institute of Cardiovascular Science, University of Birmingham, Birmingham, United Kingdom
⨯
Pushpa Patel,

Affiliation Institute of Cardiovascular Science, University of Birmingham, Birmingham, United Kingdom
⨯
Keith L. Brain,

Affiliation Institute of Cardiovascular Science, University of Birmingham, Birmingham, United Kingdom
⨯
Davor Pavlovic,

Affiliation Institute of Cardiovascular Science, University of Birmingham, Birmingham, United Kingdom
⨯
Nigel A. Brown,

Affiliation St George’s, University of London, London, United Kingdom
⨯
Larissa Fabritz ,

* E-mail: l.fabritz@bham.ac.uk

Affiliations Institute of Cardiovascular Science, University of Birmingham, Birmingham, United Kingdom, Department of Cardiovascular Medicine, Hospital of the University of Münster, Münster, Germany, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
⨯
Paulus Kirchhof

Affiliations Institute of Cardiovascular Science, University of Birmingham, Birmingham, United Kingdom, Department of Cardiovascular Medicine, Hospital of the University of Münster, Münster, Germany, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom
⨯

A Regional Reduction in I_to and I_KACh in the Murine Posterior Left Atrial Myocardium Is Associated with Action Potential Prolongation and Increased Ectopic Activity

Andrew P. Holmes,
Ting Y. Yu,
Samantha Tull,
Fahima Syeda,
Stefan M. Kuhlmann,
Sian-Marie O’Brien,
Pushpa Patel,
Keith L. Brain,
Davor Pavlovic,
Nigel A. Brown

Published: May 5, 2016
https://doi.org/10.1371/journal.pone.0154077

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