The Quantum Nature of Drug-Receptor Interactions: Deuteration Changes Binding Affinities for Histamine Receptor Ligands

• Mojca Kržan ,

  Contributed equally to this work with: Mojca Kržan, Robert Vianello, Aleksandra Maršavelski

  Affiliation Department of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

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• Robert Vianello ,

  Contributed equally to this work with: Mojca Kržan, Robert Vianello, Aleksandra Maršavelski

  Affiliation Computational Organic Chemistry and Biochemistry Group, Ruđer Bošković Institute, Zagreb, Croatia

  http://orcid.org/0000-0003-1779-4524

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• Aleksandra Maršavelski ,

  Contributed equally to this work with: Mojca Kržan, Robert Vianello, Aleksandra Maršavelski

  Affiliation Computational Organic Chemistry and Biochemistry Group, Ruđer Bošković Institute, Zagreb, Croatia

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• Matej Repič,

  Current address: Krka d.d. Pharmaceutial, Novo mesto, Slovenia

  Affiliation Laboratory for Biocomputing and Bioinformatics, National Institute of Chemistry, Ljubljana, Slovenia

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• Maja Zakšek,

  Affiliation Department of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

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• Kristina Kotnik,

  Affiliation Department of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

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• Estera Fijan,

  Affiliation Department of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

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• Janez Mavri

  * E-mail: janez.mavri@ki.si

  Affiliation Laboratory for Biocomputing and Bioinformatics, National Institute of Chemistry, Ljubljana, Slovenia

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