Combined Gene Expression and RNAi Screening to Identify Alkylation Damage Survival Pathways from Fly to Human

Alfeu Zanotto-Filho; Ravi Dashnamoorthy; Eva Loranc; Luis H. T. de Souza; José C. F. Moreira; Uthra Suresh; Yidong Chen; Alexander J. R. Bishop

doi:10.1371/journal.pone.0153970

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Open Access

Peer-reviewed

Research Article

Combined Gene Expression and RNAi Screening to Identify Alkylation Damage Survival Pathways from Fly to Human

Alfeu Zanotto-Filho,

Affiliations Greehey Children´s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
⨯
Ravi Dashnamoorthy,

Affiliations Greehey Children´s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Molecular Oncology Research Institute, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯
Eva Loranc,

Affiliation Greehey Children´s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
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Luis H. T. de Souza,

Affiliation Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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José C. F. Moreira,

Affiliation Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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Uthra Suresh,

Affiliations Greehey Children´s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Yidong Chen,

Affiliations Greehey Children´s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Alexander J. R. Bishop

* E-mail: bishopa@uthscsa.edu

Affiliations Greehey Children´s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

http://orcid.org/0000-0002-5742-4387

⨯

Combined Gene Expression and RNAi Screening to Identify Alkylation Damage Survival Pathways from Fly to Human

Alfeu Zanotto-Filho,
Ravi Dashnamoorthy,
Eva Loranc,
Luis H. T. de Souza,
José C. F. Moreira,
Uthra Suresh,
Yidong Chen,
Alexander J. R. Bishop

Published: April 21, 2016
https://doi.org/10.1371/journal.pone.0153970

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Gene expression
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RNA interference
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Genetic screens
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Peas
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Drosophila melanogaster
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Protein metabolism
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