Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src

• Jennifer LY Tsang ,

  * E-mail: tsangj10@mcmaster.ca

  Affiliations Division of Critical Care, Department of Medicine, McMaster University, Hamilton, Ontario, Canada, Division of Critical Care, Department of Medicine, Niagara Health System, Niagara, Ontario, Canada

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• Song Hui Jia,

  Affiliation Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada

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• Jean Parodo,

  Affiliation Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada

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• Pamela Plant,

  Affiliation Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada

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• Monika Lodyga,

  Affiliation Laboratory of Tissue Repair and Regeneration, Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada

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• Emmanuel Charbonney,

  Affiliations Department of Medicine, University of Montreal, Montreal, Quebec, Canada, Centre de Recherche de “Hopital du Sacre-Coeur de Montreal, Montreal, Quebec, Canada

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• Katalin Szaszi,

  Affiliations Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada, Department of Surgery, St. Michael’s Hospital, Toronto, Ontario, Canada

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• Andras Kapus ,

  ¶‡ These authors are joint senior authors on this work.

  Affiliations Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada, Department of Surgery, St. Michael’s Hospital, Toronto, Ontario, Canada

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• John C. Marshall

  ¶‡ These authors are joint senior authors on this work.

  Affiliations Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada, Department of Critical Care Medicine, St. Michael’s Hospital, Toronto, Ontario, Canada, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada

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