Mechanical Strain Causes Adaptive Change in Bronchial Fibroblasts Enhancing Profibrotic and Inflammatory Responses

Wiparat Manuyakorn; David E. Smart; Antonio Noto; Fabio Bucchieri; Hans Michael Haitchi; Stephen T. Holgate; Peter H. Howarth; Donna E. Davies

doi:10.1371/journal.pone.0153926

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Open Access

Peer-reviewed

Research Article

Mechanical Strain Causes Adaptive Change in Bronchial Fibroblasts Enhancing Profibrotic and Inflammatory Responses

Wiparat Manuyakorn,

Current address: Division of Pediatrics Allergy, Mahidol University, Bangkok, Thailand

Affiliation Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom
⨯
David E. Smart ,

* E-mail: d.smart@southampton.ac.uk

Affiliation Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom
⨯
Antonio Noto,

Affiliations Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom, BIONEC Department, University of Palermo, Palermo, Italy, Istituto Euro-Mediterraneo di Scienza e Tecnologia, IEMEST, Palermo, Italy
⨯
Fabio Bucchieri,

Affiliations BIONEC Department, University of Palermo, Palermo, Italy, Istituto Euro-Mediterraneo di Scienza e Tecnologia, IEMEST, Palermo, Italy
⨯
Hans Michael Haitchi,

Affiliations Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom, National Institute for Health Research (NIHR) Southampton Respiratory Biomedical Research Unit, Southampton Centre for Biomedical Research, Southampton General Hospital, Southampton, United Kingdom
⨯
Stephen T. Holgate,

Affiliations Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom, National Institute for Health Research (NIHR) Southampton Respiratory Biomedical Research Unit, Southampton Centre for Biomedical Research, Southampton General Hospital, Southampton, United Kingdom
⨯
Peter H. Howarth,

Affiliations Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom, National Institute for Health Research (NIHR) Southampton Respiratory Biomedical Research Unit, Southampton Centre for Biomedical Research, Southampton General Hospital, Southampton, United Kingdom
⨯
Donna E. Davies

Affiliations Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom, National Institute for Health Research (NIHR) Southampton Respiratory Biomedical Research Unit, Southampton Centre for Biomedical Research, Southampton General Hospital, Southampton, United Kingdom
⨯

Mechanical Strain Causes Adaptive Change in Bronchial Fibroblasts Enhancing Profibrotic and Inflammatory Responses

Wiparat Manuyakorn,
David E. Smart,
Antonio Noto,
Fabio Bucchieri,
Hans Michael Haitchi,
Stephen T. Holgate,
Peter H. Howarth,
Donna E. Davies

Published: April 21, 2016
https://doi.org/10.1371/journal.pone.0153926

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Fibroblasts
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Asthma
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Collagens
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Inflammation
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Extracellular matrix
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Proteoglycans
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Protein expression
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Smooth muscles
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