A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus

Marios Arvanitis; Gang Li; De-Dong Li; Daniel Cotnoir; Lisa Ganley-Leal; Daniel W. Carney; Jason K. Sello; Eleftherios Mylonakis

doi:10.1371/journal.pone.0153912

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Peer-reviewed

Research Article

A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus

Marios Arvanitis,

Affiliations Infectious Diseases Division, Rhode Island Hospital, Providence, RI, United States of America, Warren Alpert Medical School of Brown University, Providence, RI, United States of America
⨯
Gang Li,

Affiliations Infectious Diseases Division, Rhode Island Hospital, Providence, RI, United States of America, Warren Alpert Medical School of Brown University, Providence, RI, United States of America
⨯
De-Dong Li,

Affiliations Infectious Diseases Division, Rhode Island Hospital, Providence, RI, United States of America, Warren Alpert Medical School of Brown University, Providence, RI, United States of America
⨯
Daniel Cotnoir,

Affiliation Department of Pediatrics, Hasbro Children's Hospital, Brown University Alpert Medical School, Providence, RI, United States of America
⨯
Lisa Ganley-Leal,

Affiliation Department of Pediatrics, Hasbro Children's Hospital, Brown University Alpert Medical School, Providence, RI, United States of America
⨯
Daniel W. Carney,

Affiliation Department of Chemistry, Brown University, 324 Brook Street, Providence, RI, United States of America
⨯
Jason K. Sello ,

* E-mail: emylonakis@lifespan.org (EM); Jason_sello@brown.edu (JKS)

Affiliation Department of Chemistry, Brown University, 324 Brook Street, Providence, RI, United States of America
⨯
Eleftherios Mylonakis

* E-mail: emylonakis@lifespan.org (EM); Jason_sello@brown.edu (JKS)

Affiliations Infectious Diseases Division, Rhode Island Hospital, Providence, RI, United States of America, Warren Alpert Medical School of Brown University, Providence, RI, United States of America
⨯

A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus

Marios Arvanitis,
Gang Li,
De-Dong Li,
Daniel Cotnoir,
Lisa Ganley-Leal,
Daniel W. Carney,
Jason K. Sello,
Eleftherios Mylonakis

Published: April 21, 2016
https://doi.org/10.1371/journal.pone.0153912

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