Cytochrome P450 1A2 Metabolizes 17β-Estradiol to Suppress Hepatocellular Carcinoma

Jianwai Ren; George G. Chen; Yi Liu; Xianwei Su; Baoguang Hu; Billy C. S. Leung; Y. Wang; Rocky L. K. Ho; Shengli Yang; Gang Lu; C. G. Lee; Paul B. S. Lai

doi:10.1371/journal.pone.0153863

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Open Access

Peer-reviewed

Research Article

Cytochrome P450 1A2 Metabolizes 17β-Estradiol to Suppress Hepatocellular Carcinoma

Jianwai Ren,

Affiliations Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong; New Territories, Hong Kong, China, CUHK Shenzhen Research Institute (SZRI), Shenzhen, 518057, China
⨯
George G. Chen ,

* E-mail: gchen@cuhk.edu.hk (GGC); paulai@cuhk.edu.hk (PBSL)

Affiliations Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong; New Territories, Hong Kong, China, CUHK Shenzhen Research Institute (SZRI), Shenzhen, 518057, China
⨯
Yi Liu,

Affiliations Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong; New Territories, Hong Kong, China, Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang, Guangdong, China
⨯
Xianwei Su,

Affiliation Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong; New Territories, Hong Kong, China
⨯
Baoguang Hu,

Affiliation Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong; New Territories, Hong Kong, China
⨯
Billy C. S. Leung,

Affiliation Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong; New Territories, Hong Kong, China
⨯
Y. Wang,

Affiliation National Cancer Centre, Division of Medical Sciences, Singapore, Singapore
⨯
Rocky L. K. Ho,

Affiliation Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong; New Territories, Hong Kong, China
⨯
Shengli Yang,

Affiliation Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong; New Territories, Hong Kong, China
⨯
Gang Lu,

Affiliation Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong; New Territories, Hong Kong, China
⨯
C. G. Lee,

Affiliation National Cancer Centre, Division of Medical Sciences, Singapore, Singapore
⨯
Paul B. S. Lai

Affiliation Department of Surgery, Faculty of Medicine, The Chinese University of Hong Kong; New Territories, Hong Kong, China
⨯

Cytochrome P450 1A2 Metabolizes 17β-Estradiol to Suppress Hepatocellular Carcinoma

Jianwai Ren,
George G. Chen,
Yi Liu,
Xianwei Su,
Baoguang Hu,
Billy C. S. Leung,
Y. Wang,
Rocky L. K. Ho,
Shengli Yang,
Gang Lu

Published: April 19, 2016
https://doi.org/10.1371/journal.pone.0153863

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Estrogens
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Transfection
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