Toll-Like Receptor 1/2 and 5 Ligands Enhance the Expression of Cyclin D1 and D3 and Induce Proliferation in Mantle Cell Lymphoma

Katy Mastorci; Elena Muraro; Elisa Pasini; Chiara Furlan; Luca Sigalotti; Marina Cinco; Riccardo Dolcetti; Elisabetta Fratta

doi:10.1371/journal.pone.0153823

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Open Access

Peer-reviewed

Research Article

Toll-Like Receptor 1/2 and 5 Ligands Enhance the Expression of Cyclin D1 and D3 and Induce Proliferation in Mantle Cell Lymphoma

Katy Mastorci,

Affiliation Cancer Bio-Immunotherapy Unit, Department of Translational Research, Centro di Riferimento Oncologico, IRCCS—National Cancer Institute, Aviano (PN), Italy
⨯
Elena Muraro ,

* E-mail: elemuraro@gmail.com

Affiliation Cancer Bio-Immunotherapy Unit, Department of Translational Research, Centro di Riferimento Oncologico, IRCCS—National Cancer Institute, Aviano (PN), Italy
⨯
Elisa Pasini,

Affiliations Cancer Bio-Immunotherapy Unit, Department of Translational Research, Centro di Riferimento Oncologico, IRCCS—National Cancer Institute, Aviano (PN), Italy, Princess Margaret Cancer Centre, University Health Network and TECHNA Institute for the Advancement of Technology for Health, TMDT, Room 11–314, 101 College Street, Toronto, ON M5G 1L7, Canada
⨯
Chiara Furlan,

Affiliation Cancer Bio-Immunotherapy Unit, Department of Translational Research, Centro di Riferimento Oncologico, IRCCS—National Cancer Institute, Aviano (PN), Italy
⨯
Luca Sigalotti,

Affiliation Cancer Bio-Immunotherapy Unit, Department of Translational Research, Centro di Riferimento Oncologico, IRCCS—National Cancer Institute, Aviano (PN), Italy
⨯
Marina Cinco,

Affiliation Spirochete Laboratory, Department of Life Sciences, University of Trieste, Trieste, Italy
⨯
Riccardo Dolcetti ,

¶‡ These authors shared senior authorship on this work.

Affiliations Cancer Bio-Immunotherapy Unit, Department of Translational Research, Centro di Riferimento Oncologico, IRCCS—National Cancer Institute, Aviano (PN), Italy, University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia
⨯
Elisabetta Fratta

* E-mail: elemuraro@gmail.com

¶‡ These authors shared senior authorship on this work.

Affiliation Cancer Bio-Immunotherapy Unit, Department of Translational Research, Centro di Riferimento Oncologico, IRCCS—National Cancer Institute, Aviano (PN), Italy
⨯

Toll-Like Receptor 1/2 and 5 Ligands Enhance the Expression of Cyclin D1 and D3 and Induce Proliferation in Mantle Cell Lymphoma

Katy Mastorci,
Elena Muraro,
Elisa Pasini,
Chiara Furlan,
Luca Sigalotti,
Marina Cinco,
Riccardo Dolcetti,
Elisabetta Fratta

Published: April 28, 2016
https://doi.org/10.1371/journal.pone.0153823

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Cyclins
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B cells
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Toll-like receptors
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Borrelia infection
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MAPK signaling cascades
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Lymphoma
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Transcription factors
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Immune receptor signaling
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