MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension

Sanghamitra Sahoo; Daniel N. Meijles; Imad Al Ghouleh; Manuj Tandon; Eugenia Cifuentes-Pagano; John Sembrat; Mauricio Rojas; Elena Goncharova; Patrick J. Pagano

doi:10.1371/journal.pone.0153780

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Research Article

MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension

Sanghamitra Sahoo,

Affiliations Department of Pharmacology and Chemical Biology University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America
⨯
Daniel N. Meijles,

Current address: Institute of Cardiovascular and Metabolic Research, University of Reading, Whiteknights, Reading, RG6 6AS, United Kingdom

Affiliations Department of Pharmacology and Chemical Biology University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America
⨯
Imad Al Ghouleh,

Affiliations Department of Pharmacology and Chemical Biology University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America
⨯
Manuj Tandon,

Affiliation Department of Pharmacology and Chemical Biology University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America
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Eugenia Cifuentes-Pagano,

Affiliations Department of Pharmacology and Chemical Biology University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America
⨯
John Sembrat,

Affiliations Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America
⨯
Mauricio Rojas,

Affiliations Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America
⨯
Elena Goncharova,

Affiliations Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America
⨯
Patrick J. Pagano

* E-mail: pagano@pitt.edu

Affiliations Department of Pharmacology and Chemical Biology University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, United States of America
⨯

MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension

Sanghamitra Sahoo,
Daniel N. Meijles,
Imad Al Ghouleh,
Manuj Tandon,
Eugenia Cifuentes-Pagano,
John Sembrat,
Mauricio Rojas,
Elena Goncharova,
Patrick J. Pagano

Published: May 4, 2016
https://doi.org/10.1371/journal.pone.0153780

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Transfection
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