The Effect of Sorafenib, Tadalafil and Macitentan Treatments on Thyroxin-Induced Hemodynamic Changes and Cardiac Abnormalities

Nancy S. Saad; Kyle Floyd; Amany A. E. Ahmed; Peter J. Mohler; Paul M. L. Janssen; Mohammad T. Elnakish

doi:10.1371/journal.pone.0153694

Loading metrics

Open Access

Peer-reviewed

Research Article

The Effect of Sorafenib, Tadalafil and Macitentan Treatments on Thyroxin-Induced Hemodynamic Changes and Cardiac Abnormalities

Nancy S. Saad,

Affiliations Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America, Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University, Columbus, Ohio, United States of America, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Cairo, Egypt
⨯
Kyle Floyd,

Affiliations Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America, Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University, Columbus, Ohio, United States of America
⨯
Amany A. E. Ahmed,

Affiliation Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Cairo, Egypt
⨯
Peter J. Mohler,

Affiliations Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America, Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University, Columbus, Ohio, United States of America
⨯
Paul M. L. Janssen ,

Contributed equally to this work with: Paul M. L. Janssen, Mohammad T. Elnakish

Affiliations Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America, Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University, Columbus, Ohio, United States of America
⨯
Mohammad T. Elnakish

Contributed equally to this work with: Paul M. L. Janssen, Mohammad T. Elnakish

* E-mail: elnakish.1@osu.edu

Affiliations Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America, Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University, Columbus, Ohio, United States of America, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Cairo, Egypt
⨯

The Effect of Sorafenib, Tadalafil and Macitentan Treatments on Thyroxin-Induced Hemodynamic Changes and Cardiac Abnormalities

Nancy S. Saad,
Kyle Floyd,
Amany A. E. Ahmed,
Peter J. Mohler,
Paul M. L. Janssen,
Mohammad T. Elnakish

Published: April 15, 2016
https://doi.org/10.1371/journal.pone.0153694

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Blood pressure
Is the Subject Area "Blood pressure" applicable to this article?

Thanks for your feedback.
Cardiac hypertrophy
Is the Subject Area "Cardiac hypertrophy" applicable to this article?

Thanks for your feedback.
Papillary muscles
Is the Subject Area "Papillary muscles" applicable to this article?

Thanks for your feedback.
Drug therapy
Is the Subject Area "Drug therapy" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Electrocardiography
Is the Subject Area "Electrocardiography" applicable to this article?

Thanks for your feedback.
Heart
Is the Subject Area "Heart" applicable to this article?

Thanks for your feedback.
Echocardiography
Is the Subject Area "Echocardiography" applicable to this article?

Thanks for your feedback.