Evaluation of New Diagnostic Biomarkers in Pediatric Sepsis: Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, Mid-Regional Pro-Atrial Natriuretic Peptide, and Adipocyte Fatty-Acid Binding Protein

Mashael F. Alqahtani; Craig M. Smith; Scott L. Weiss; Susan Dawson; Hantamalala Ralay Ranaivo; Mark S. Wainwright

doi:10.1371/journal.pone.0153645

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Research Article

Evaluation of New Diagnostic Biomarkers in Pediatric Sepsis: Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, Mid-Regional Pro-Atrial Natriuretic Peptide, and Adipocyte Fatty-Acid Binding Protein

Mashael F. Alqahtani,

Affiliation Department of Pediatrics, Divisions of Critical Care, Ann & Robert. H. Lurie Children’s Hospital of Chicago, Northwestern Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯
Craig M. Smith,

Affiliations Department of Pediatrics, Divisions of Critical Care, Ann & Robert. H. Lurie Children’s Hospital of Chicago, Northwestern Feinberg School of Medicine, Chicago, Illinois, United States of America, Department of Pediatrics, Divisions of Neurology, Ann & Robert. H. Lurie Children’s Hospital of Chicago, Northwestern Feinberg School of Medicine, Chicago, Illinois, United States of America, Ruth D. & Ken M. Davee Pediatric Neurocritical Care Program, Ann & Robert. H. Lurie Children’s Hospital of Chicago, Northwestern Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯
Scott L. Weiss,

Affiliation Department of Anesthesiology and Critical Care Medicine, The Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Susan Dawson,

Affiliation Department of Pathology and Laboratory Medicine, Swedish Covenant Hospital, Chicago, Illinois, United States of America
⨯
Hantamalala Ralay Ranaivo,

Affiliation Ruth D. & Ken M. Davee Pediatric Neurocritical Care Program, Ann & Robert. H. Lurie Children’s Hospital of Chicago, Northwestern Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯
Mark S. Wainwright

* E-mail: m-wainwright@northwestern.edu

Affiliations Department of Pediatrics, Divisions of Critical Care, Ann & Robert. H. Lurie Children’s Hospital of Chicago, Northwestern Feinberg School of Medicine, Chicago, Illinois, United States of America, Department of Pediatrics, Divisions of Neurology, Ann & Robert. H. Lurie Children’s Hospital of Chicago, Northwestern Feinberg School of Medicine, Chicago, Illinois, United States of America, Ruth D. & Ken M. Davee Pediatric Neurocritical Care Program, Ann & Robert. H. Lurie Children’s Hospital of Chicago, Northwestern Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯

Evaluation of New Diagnostic Biomarkers in Pediatric Sepsis: Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, Mid-Regional Pro-Atrial Natriuretic Peptide, and Adipocyte Fatty-Acid Binding Protein

Mashael F. Alqahtani,
Craig M. Smith,
Scott L. Weiss,
Susan Dawson,
Hantamalala Ralay Ranaivo,
Mark S. Wainwright

Published: April 18, 2016
https://doi.org/10.1371/journal.pone.0153645

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Sepsis
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Biomarkers
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Pediatrics
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Severe sepsis
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C-reactive proteins
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Atrial natriuretic peptide
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Developmental and pediatric neurology
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