Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY® System

Ka-Wai Cheung; Qiaoli Peng; Liufen He; Kanru Cai; Qiang Jiang; Boping Zhou; Sabrina Wai-Chi To; Wing-Cheong Yam; Li Liu; Zhiwei Chen; Hui Wang

doi:10.1371/journal.pone.0153641

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Open Access

Peer-reviewed

Research Article

Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY® System

Ka-Wai Cheung ,

Contributed equally to this work with: Ka-Wai Cheung, Qiaoli Peng

Affiliation AIDS Institute and Department of Microbiology, Research Centre for Infection and Immunity, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, People’s Republic of China
⨯
Qiaoli Peng ,

Contributed equally to this work with: Ka-Wai Cheung, Qiaoli Peng

Affiliation HKU-AIDS Institute Shenzhen Research Laboratory and AIDS Clinical Research Laboratory, Guangdong Key Lab of Emerging Infectious Diseases and Shenzhen Key Lab of Infection and Immunity, Shenzhen Third People’s Hospital, Guangdong Medical College, Shenzhen, People’s Republic of China
⨯
Liufen He,

Affiliation HKU-AIDS Institute Shenzhen Research Laboratory and AIDS Clinical Research Laboratory, Guangdong Key Lab of Emerging Infectious Diseases and Shenzhen Key Lab of Infection and Immunity, Shenzhen Third People’s Hospital, Guangdong Medical College, Shenzhen, People’s Republic of China
⨯
Kanru Cai,

Affiliation HKU-AIDS Institute Shenzhen Research Laboratory and AIDS Clinical Research Laboratory, Guangdong Key Lab of Emerging Infectious Diseases and Shenzhen Key Lab of Infection and Immunity, Shenzhen Third People’s Hospital, Guangdong Medical College, Shenzhen, People’s Republic of China
⨯
Qiang Jiang,

Affiliation HKU-AIDS Institute Shenzhen Research Laboratory and AIDS Clinical Research Laboratory, Guangdong Key Lab of Emerging Infectious Diseases and Shenzhen Key Lab of Infection and Immunity, Shenzhen Third People’s Hospital, Guangdong Medical College, Shenzhen, People’s Republic of China
⨯
Boping Zhou,

Affiliation HKU-AIDS Institute Shenzhen Research Laboratory and AIDS Clinical Research Laboratory, Guangdong Key Lab of Emerging Infectious Diseases and Shenzhen Key Lab of Infection and Immunity, Shenzhen Third People’s Hospital, Guangdong Medical College, Shenzhen, People’s Republic of China
⨯
Sabrina Wai-Chi To,

Affiliation Department of Microbiology, The University of Hong Kong, Hong Kong SAR, People’s Republic of China
⨯
Wing-Cheong Yam,

Affiliation Department of Microbiology, The University of Hong Kong, Hong Kong SAR, People’s Republic of China
⨯
Li Liu,

Affiliation AIDS Institute and Department of Microbiology, Research Centre for Infection and Immunity, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, People’s Republic of China
⨯
Zhiwei Chen ,

* E-mail: huiwang98@yahoo.com (HW); zchenai@hku.hk (ZC)

Affiliation AIDS Institute and Department of Microbiology, Research Centre for Infection and Immunity, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, People’s Republic of China
⨯
Hui Wang

* E-mail: huiwang98@yahoo.com (HW); zchenai@hku.hk (ZC)

Affiliation HKU-AIDS Institute Shenzhen Research Laboratory and AIDS Clinical Research Laboratory, Guangdong Key Lab of Emerging Infectious Diseases and Shenzhen Key Lab of Infection and Immunity, Shenzhen Third People’s Hospital, Guangdong Medical College, Shenzhen, People’s Republic of China
⨯

Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY® System

Ka-Wai Cheung,
Qiaoli Peng,
Liufen He,
Kanru Cai,
Qiang Jiang,
Boping Zhou,
Sabrina Wai-Chi To,
Wing-Cheong Yam,
Li Liu,
Zhiwei Chen

Published: April 19, 2016
https://doi.org/10.1371/journal.pone.0153641

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Matrix-assisted laser desorption ionization time-of-flight mass spectrometry
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