Detection of BRAF Mutations Using a Fully Automated Platform and Comparison with High Resolution Melting, Real-Time Allele Specific Amplification, Immunohistochemistry and Next Generation Sequencing Assays, for Patients with Metastatic Melanoma

Open Access

Peer-reviewed

Research Article

Alexandre Harlé ,

* E-mail: a.harle@nancy.unicancer.fr

Affiliations Université de Lorraine, Faculté de Pharmacie, Nancy, France, CNRS UMR 7039 CRAN, Nancy, France, Institut de Cancérologie de Lorraine, Service de Biopathologie, Vandoeuvre-lès-Nancy, France
⨯
Julia Salleron,

Affiliations Institut de Cancérologie de Lorraine, Service de Biopathologie, Vandoeuvre-lès-Nancy, France, Institut de Cancérologie de Lorraine, Cellule biostatistique, Vandoeuvre-lès-Nancy, France
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Claire Franczak,

Affiliation Institut de Cancérologie de Lorraine, Service de Biopathologie, Vandoeuvre-lès-Nancy, France
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Cindy Dubois,

Affiliation Institut de Cancérologie de Lorraine, Service de Biopathologie, Vandoeuvre-lès-Nancy, France
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Pierre Filhine-Tressarieu,

Affiliation Institut de Cancérologie de Lorraine, Service de Biopathologie, Vandoeuvre-lès-Nancy, France
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Agnès Leroux,

Affiliations CNRS UMR 7039 CRAN, Nancy, France, Institut de Cancérologie de Lorraine, Service de Biopathologie, Vandoeuvre-lès-Nancy, France
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Jean-Louis Merlin

Affiliations Université de Lorraine, Faculté de Pharmacie, Nancy, France, CNRS UMR 7039 CRAN, Nancy, France, Institut de Cancérologie de Lorraine, Service de Biopathologie, Vandoeuvre-lès-Nancy, France
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Mutation detection
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Immunohistochemistry techniques
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Mutation
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Next-generation sequencing
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Melanoma
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Polymerase chain reaction
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Metastasis
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DNA extraction
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