Bilirubin Binding to PPARα Inhibits Lipid Accumulation

David E. Stec; Kezia John; Christopher J. Trabbic; Amarjit Luniwal; Michael W. Hankins; Justin Baum; Terry D. Hinds Jr.

doi:10.1371/journal.pone.0153427

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Open Access

Peer-reviewed

Research Article

Bilirubin Binding to PPARα Inhibits Lipid Accumulation

David E. Stec,

Affiliation Cardiovascular-Renal Research Center, Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State St, Jackson, Mississippi, 39216, United States of America
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Kezia John,

Affiliation Center for Hypertension and Personalized Medicine, Department of Physiology & Pharmacology, University of Toledo College of Medicine, Toledo, OH, 43614, United States of America
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Christopher J. Trabbic,

Affiliation Center for Drug Design and Development, University of Toledo College of Pharmacy and Pharmaceutical Sciences, Toledo, OH, 43614, United States of America
⨯
Amarjit Luniwal,

Affiliations Center for Drug Design and Development, University of Toledo College of Pharmacy and Pharmaceutical Sciences, Toledo, OH, 43614, United States of America, North American Science Associates, Inc. (NAMSA), 6750 Wales Rd, Northwood, Ohio, 43619, United States of America
⨯
Michael W. Hankins,

Affiliation Cardiovascular-Renal Research Center, Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State St, Jackson, Mississippi, 39216, United States of America
⨯
Justin Baum,

Affiliation Center for Hypertension and Personalized Medicine, Department of Physiology & Pharmacology, University of Toledo College of Medicine, Toledo, OH, 43614, United States of America
⨯
Terry D. Hinds Jr.

* E-mail: Terry.Hinds@utoledo.edu

Affiliation Center for Hypertension and Personalized Medicine, Department of Physiology & Pharmacology, University of Toledo College of Medicine, Toledo, OH, 43614, United States of America

http://orcid.org/0000-0002-7599-1529

⨯

Bilirubin Binding to PPARα Inhibits Lipid Accumulation

David E. Stec,
Kezia John,
Christopher J. Trabbic,
Amarjit Luniwal,
Michael W. Hankins,
Justin Baum,
Terry D. Hinds Jr.

Published: April 12, 2016
https://doi.org/10.1371/journal.pone.0153427

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Bilirubin
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Blood plasma
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Adipose tissue
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Lipids
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Fibroblast growth factor
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Gene regulation
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Obesity
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Aminotransferases
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