Hydroxysafflor Yellow A Ameliorates Renal Fibrosis by Suppressing TGF-β1-Induced Epithelial-to-Mesenchymal Transition

Naping Hu; Jialin Duan; Huihui Li; Yanhua Wang; Fang Wang; Jianjie Chu; Jin Sun; Meiyou Liu; Chao Wang; Chengtao Lu; Aidong Wen

doi:10.1371/journal.pone.0153409

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Open Access

Peer-reviewed

Research Article

Hydroxysafflor Yellow A Ameliorates Renal Fibrosis by Suppressing TGF-β1-Induced Epithelial-to-Mesenchymal Transition

Naping Hu ,

Contributed equally to this work with: Naping Hu, Jialin Duan, Huihui Li, Yanhua Wang, Fang Wang

Affiliations Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, China, College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, China
⨯
Jialin Duan ,

Contributed equally to this work with: Naping Hu, Jialin Duan, Huihui Li, Yanhua Wang, Fang Wang

Affiliations Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, China, College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, China
⨯
Huihui Li ,

Contributed equally to this work with: Naping Hu, Jialin Duan, Huihui Li, Yanhua Wang, Fang Wang

Affiliations Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, China, College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, China
⨯
Yanhua Wang ,

Contributed equally to this work with: Naping Hu, Jialin Duan, Huihui Li, Yanhua Wang, Fang Wang

Affiliation College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, China
⨯
Fang Wang ,

Contributed equally to this work with: Naping Hu, Jialin Duan, Huihui Li, Yanhua Wang, Fang Wang

Affiliations Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, China, College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, China
⨯
Jianjie Chu,

Affiliations Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, China, College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, China
⨯
Jin Sun,

Affiliations Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, China, College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, China
⨯
Meiyou Liu,

Affiliation Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, China
⨯
Chao Wang,

Affiliation Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, China
⨯
Chengtao Lu ,

* E-mail: 18991397171@163.com (ADW); lu-009@163.com (CTL)

Affiliation Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, China
⨯
Aidong Wen

* E-mail: 18991397171@163.com (ADW); lu-009@163.com (CTL)

Affiliations Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, China, College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, China
⨯

Hydroxysafflor Yellow A Ameliorates Renal Fibrosis by Suppressing TGF-β1-Induced Epithelial-to-Mesenchymal Transition

Naping Hu,
Jialin Duan,
Huihui Li,
Yanhua Wang,
Fang Wang,
Jianjie Chu,
Jin Sun,
Meiyou Liu,
Chao Wang,
Chengtao Lu

Published: April 18, 2016
https://doi.org/10.1371/journal.pone.0153409

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Fibrosis
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Kidneys
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SMAD signaling
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