Histone Deacetylase Inhibitors Trichostatin A and MCP30 Relieve Benzene-Induced Hematotoxicity via Restoring Topoisomerase IIα

Jingjing Chen; Zhouyi Zheng; Yi Chen; Jiaqi Li; Shanhu Qian; Yifen Shi; Lan Sun; Yixiang Han; Shenghui Zhang; Kang Yu

doi:10.1371/journal.pone.0153330

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Open Access

Peer-reviewed

Research Article

Histone Deacetylase Inhibitors Trichostatin A and MCP30 Relieve Benzene-Induced Hematotoxicity via Restoring Topoisomerase IIα

Jingjing Chen ,

Contributed equally to this work with: Jingjing Chen, Zhouyi Zheng

Affiliation Department of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China
⨯
Zhouyi Zheng ,

Contributed equally to this work with: Jingjing Chen, Zhouyi Zheng

Affiliation Department of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China
⨯
Yi Chen,

Affiliation Department of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China
⨯
Jiaqi Li,

Affiliation Department of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China
⨯
Shanhu Qian,

Affiliation Department of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China
⨯
Yifen Shi,

Affiliation Department of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China
⨯
Lan Sun,

Affiliation Department of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China
⨯
Yixiang Han,

Affiliation Laboratory of Internal Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China
⨯
Shenghui Zhang ,

* E-mail: shenghuizhang1@126.com (SZ); yukang62@126.com (KY)

Affiliation Department of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China
⨯
Kang Yu

* E-mail: shenghuizhang1@126.com (SZ); yukang62@126.com (KY)

Affiliation Department of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China
⨯

Histone Deacetylase Inhibitors Trichostatin A and MCP30 Relieve Benzene-Induced Hematotoxicity via Restoring Topoisomerase IIα

Jingjing Chen,
Zhouyi Zheng,
Yi Chen,
Jiaqi Li,
Shanhu Qian,
Yifen Shi,
Lan Sun,
Yixiang Han,
Shenghui Zhang,
Kang Yu

Published: April 8, 2016
https://doi.org/10.1371/journal.pone.0153330

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Benzene
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Bone marrow cells
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Histones
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Histone acetylation
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