The Host Response to a Clinical MDR Mycobacterial Strain Cultured in a Detergent-Free Environment: A Global Transcriptomics Approach

Gina Leisching; Ray-Dean Pietersen; Vuyiseka Mpongoshe; Carel van Heerden; Paul van Helden; Ian Wiid; Bienyameen Baker

doi:10.1371/journal.pone.0153079

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Open Access

Peer-reviewed

Research Article

The Host Response to a Clinical MDR Mycobacterial Strain Cultured in a Detergent-Free Environment: A Global Transcriptomics Approach

Gina Leisching ,

* E-mail: ginal@sun.ac.za

Affiliation SA MRC Centre for TB Research, DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa
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Ray-Dean Pietersen,

Affiliation SA MRC Centre for TB Research, DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa
⨯
Vuyiseka Mpongoshe,

Affiliation SA MRC Centre for TB Research, DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa
⨯
Carel van Heerden,

Affiliation Central Analytical Facility (CAF), DNA sequencing unit, Stellenbosch University, Stellenbosch, South Africa
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Paul van Helden,

Affiliation SA MRC Centre for TB Research, DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa
⨯
Ian Wiid,

Affiliation SA MRC Centre for TB Research, DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa
⨯
Bienyameen Baker

Affiliation SA MRC Centre for TB Research, DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa
⨯

The Host Response to a Clinical MDR Mycobacterial Strain Cultured in a Detergent-Free Environment: A Global Transcriptomics Approach

Gina Leisching,
Ray-Dean Pietersen,
Vuyiseka Mpongoshe,
Carel van Heerden,
Paul van Helden,
Ian Wiid,
Bienyameen Baker

Published: April 7, 2016
https://doi.org/10.1371/journal.pone.0153079

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Gene expression
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Host cells
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Mycobacterium tuberculosis
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Pattern recognition receptors
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Macrophages
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Detergents
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Immune response
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