Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression

Émilie Pepin; Anfal Al-Mass; Camille Attané; Kezhuo Zhang; Julien Lamontagne; Roxane Lussier; S. R. Murthy Madiraju; Erik Joly; Neil B. Ruderman; Robert Sladek; Marc Prentki; Marie-Line Peyot

doi:10.1371/journal.pone.0153017

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Peer-reviewed

Research Article

Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression

Émilie Pepin,

Affiliation Montreal Diabetes Research Center and Centre de Recherche du CHUM, Montréal, Québec, Canada
⨯
Anfal Al-Mass,

Affiliations Montreal Diabetes Research Center and Centre de Recherche du CHUM, Montréal, Québec, Canada, Departments of Medicine and Human Genetics, McGill University, Montreal, Québec, Canada
⨯
Camille Attané,

Affiliation Montreal Diabetes Research Center and Centre de Recherche du CHUM, Montréal, Québec, Canada
⨯
Kezhuo Zhang,

Affiliation Departments of Medicine and Human Genetics, McGill University, Montreal, Québec, Canada
⨯
Julien Lamontagne,

Affiliation Montreal Diabetes Research Center and Centre de Recherche du CHUM, Montréal, Québec, Canada
⨯
Roxane Lussier,

Affiliation Montreal Diabetes Research Center and Centre de Recherche du CHUM, Montréal, Québec, Canada
⨯
S. R. Murthy Madiraju,

Affiliation Montreal Diabetes Research Center and Centre de Recherche du CHUM, Montréal, Québec, Canada
⨯
Erik Joly,

Affiliation Montreal Diabetes Research Center and Centre de Recherche du CHUM, Montréal, Québec, Canada
⨯
Neil B. Ruderman,

Affiliation Departments of Medicine and Physiology and Biophysics, Boston University School of Medicine and Diabetes Unit, Boston Medical Center, Boston, MA, United States of America
⨯
Robert Sladek,

Affiliation Departments of Medicine and Human Genetics, McGill University, Montreal, Québec, Canada
⨯
Marc Prentki ,

* E-mail: marc.prentki@umontreal.ca (MP); marie-line.peyot@crchum.qc.ca (MLP)

Affiliations Montreal Diabetes Research Center and Centre de Recherche du CHUM, Montréal, Québec, Canada, Departments of Nutrition, Biochemistry and Molecular Medicine, Faculty of Medicine, University of Montréal, Montreal, Québec, Canada
⨯
Marie-Line Peyot

* E-mail: marc.prentki@umontreal.ca (MP); marie-line.peyot@crchum.qc.ca (MLP)

Affiliation Montreal Diabetes Research Center and Centre de Recherche du CHUM, Montréal, Québec, Canada
⨯

Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression

Émilie Pepin,
Anfal Al-Mass,
Camille Attané,
Kezhuo Zhang,
Julien Lamontagne,
Roxane Lussier,
S. R. Murthy Madiraju,
Erik Joly,
Neil B. Ruderman,
Robert Sladek

Published: April 4, 2016
https://doi.org/10.1371/journal.pone.0153017

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Glucose
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Cholesterol
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Mitochondria
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Gene expression
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Diet
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Insulin secretion
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Obesity
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