Early CD4+ T Cell Responses Are Associated with Subsequent CD8+ T Cell Responses to an rAd5-Based Prophylactic Prime-Boost HIV Vaccine Strategy

Edouard Lhomme; Laura Richert; Zoe Moodie; Chloé Pasin; Spyros A. Kalams; Cecilia Morgan; Steve Self; Stephen C. De Rosa; Rodolphe Thiébaut

doi:10.1371/journal.pone.0152952

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Open Access

Peer-reviewed

Research Article

Early CD4+ T Cell Responses Are Associated with Subsequent CD8+ T Cell Responses to an rAd5-Based Prophylactic Prime-Boost HIV Vaccine Strategy

Edouard Lhomme,

Affiliations INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France, Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France, CHU de Bordeaux, Pôle de santé publique, Bordeaux, France, INRIA SISTM, Talence, France, Vaccine Research Institute (VRI), Créteil, France
⨯
Laura Richert,

Affiliations INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France, Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France, CHU de Bordeaux, Pôle de santé publique, Bordeaux, France, INRIA SISTM, Talence, France, Vaccine Research Institute (VRI), Créteil, France
⨯
Zoe Moodie,

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, United States of America, HIV Vaccine Trials Network, Seattle, Washington, 98109, United States of America
⨯
Chloé Pasin,

Affiliations INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France, Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France, INRIA SISTM, Talence, France
⨯
Spyros A. Kalams,

Affiliation Infectious Diseases Unit, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232, United States of America
⨯
Cecilia Morgan,

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, United States of America, HIV Vaccine Trials Network, Seattle, Washington, 98109, United States of America
⨯
Steve Self,

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, United States of America, HIV Vaccine Trials Network, Seattle, Washington, 98109, United States of America
⨯
Stephen C. De Rosa,

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, United States of America, HIV Vaccine Trials Network, Seattle, Washington, 98109, United States of America
⨯
Rodolphe Thiébaut

* E-mail: rodolphe.thiebaut@isped.u-bordeaux2.fr

Affiliations INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France, Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France, CHU de Bordeaux, Pôle de santé publique, Bordeaux, France, INRIA SISTM, Talence, France, Vaccine Research Institute (VRI), Créteil, France
⨯

Early CD4+ T Cell Responses Are Associated with Subsequent CD8+ T Cell Responses to an rAd5-Based Prophylactic Prime-Boost HIV Vaccine Strategy

Edouard Lhomme,
Laura Richert,
Zoe Moodie,
Chloé Pasin,
Spyros A. Kalams,
Cecilia Morgan,
Steve Self,
Stephen C. De Rosa,
Rodolphe Thiébaut

Published: April 28, 2016
https://doi.org/10.1371/journal.pone.0152952

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