Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice

Vengadeshprabhu Karuppagounder; Vijayasree V. Giridharan; Somasundaram Arumugam; Remya Sreedhar; Suresh S. Palaniyandi; Prasanna Krishnamurthy; Joao Quevedo; Kenichi Watanabe; Tetsuya Konishi; Rajarajan A. Thandavarayan

doi:10.1371/journal.pone.0152922

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Peer-reviewed

Research Article

Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice

Vengadeshprabhu Karuppagounder ,

Contributed equally to this work with: Vengadeshprabhu Karuppagounder, Vijayasree V. Giridharan

Affiliation Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata 956–8603, Japan
⨯
Vijayasree V. Giridharan ,

Contributed equally to this work with: Vengadeshprabhu Karuppagounder, Vijayasree V. Giridharan

Affiliation Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, TX 77054, United States of America
⨯
Somasundaram Arumugam,

Affiliation Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata 956–8603, Japan
⨯
Remya Sreedhar,

Affiliation Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata 956–8603, Japan
⨯
Suresh S. Palaniyandi,

Affiliation Division of Hypertension and Vascular Research, Henry Ford Health System, Detroit, MI 48202, United States of America
⨯
Prasanna Krishnamurthy,

Affiliation Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030, United States of America
⨯
Joao Quevedo,

Affiliation Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, TX 77054, United States of America
⨯
Kenichi Watanabe,

Affiliation Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata 956–8603, Japan
⨯
Tetsuya Konishi,

Affiliations Basic studies on second generation functional foods, NUPALS Liaison R/D promotion division, Higashijima 265–1, Akiha-ku, Niigata, Japan, Changchun University of Chinese Medicine, Bosuo Road #1035 Jingyue Economic Development District, Changchun, RP China
⨯
Rajarajan A. Thandavarayan

* E-mail: atrajarajan@gmail.com

Affiliation Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030, United States of America
⨯

Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice

Vengadeshprabhu Karuppagounder,
Vijayasree V. Giridharan,
Somasundaram Arumugam,
Remya Sreedhar,
Suresh S. Palaniyandi,
Prasanna Krishnamurthy,
Joao Quevedo,
Kenichi Watanabe,
Tetsuya Konishi,
Rajarajan A. Thandavarayan

Published: April 12, 2016
https://doi.org/10.1371/journal.pone.0152922

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