Total Mechanical Unloading Minimizes Metabolic Demand of Left Ventricle and Dramatically Reduces Infarct Size in Myocardial Infarction

Keita Saku; Takamori Kakino; Takahiro Arimura; Takafumi Sakamoto; Takuya Nishikawa; Kazuo Sakamoto; Masataka Ikeda; Takuya Kishi; Tomomi Ide; Kenji Sunagawa

doi:10.1371/journal.pone.0152911

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Open Access

Peer-reviewed

Research Article

Total Mechanical Unloading Minimizes Metabolic Demand of Left Ventricle and Dramatically Reduces Infarct Size in Myocardial Infarction

Keita Saku ,

* E-mail: saku@cardiol.med.kyushu-u.ac.jp

Affiliation Department of Therapeutic Regulation of Cardiovascular Homeostasis, Center for Disruptive Cardiovascular Medicine, Kyushu University, Fukuoka, Japan
⨯
Takamori Kakino,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Takahiro Arimura,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Takafumi Sakamoto,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Takuya Nishikawa,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Kazuo Sakamoto,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Masataka Ikeda,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Takuya Kishi,

Affiliation Collaborative Research Institute of Innovative Therapeutics for Cardiovascular Diseases, Center for Disruptive Cardiovascular Medicine, Kyushu University, Fukuoka, Japan
⨯
Tomomi Ide,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Kenji Sunagawa

Affiliation Department of Therapeutic Regulation of Cardiovascular Homeostasis, Center for Disruptive Cardiovascular Medicine, Kyushu University, Fukuoka, Japan
⨯

Total Mechanical Unloading Minimizes Metabolic Demand of Left Ventricle and Dramatically Reduces Infarct Size in Myocardial Infarction

Keita Saku,
Takamori Kakino,
Takahiro Arimura,
Takafumi Sakamoto,
Takuya Nishikawa,
Kazuo Sakamoto,
Masataka Ikeda,
Takuya Kishi,
Tomomi Ide,
Kenji Sunagawa

Published: April 28, 2016
https://doi.org/10.1371/journal.pone.0152911

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