Proteomic Characterization of Middle Ear Fluid Confirms Neutrophil Extracellular Traps as a Predominant Innate Immune Response in Chronic Otitis Media

Stephanie Val; Marian Poley; Kristy Brown; Rachel Choi; Stephanie Jeong; Annie Colberg-Poley; Mary C. Rose; Karuna C. Panchapakesan; Joe C. Devaney; Marcos Perez-Losada; Diego Preciado

doi:10.1371/journal.pone.0152865

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Open Access

Peer-reviewed

Research Article

Proteomic Characterization of Middle Ear Fluid Confirms Neutrophil Extracellular Traps as a Predominant Innate Immune Response in Chronic Otitis Media

Stephanie Val,

Affiliation Sheikh Zayed Center for Pediatric Surgical Innovation, Children’s National Health System, Washington, DC, United States of America
⨯
Marian Poley,

Affiliation Sheikh Zayed Center for Pediatric Surgical Innovation, Children’s National Health System, Washington, DC, United States of America
⨯
Kristy Brown,

Affiliation Center for Genetic Medicine Research, Children’s National Health System, Washington, DC, United States of America
⨯
Rachel Choi,

Affiliation Sheikh Zayed Center for Pediatric Surgical Innovation, Children’s National Health System, Washington, DC, United States of America
⨯
Stephanie Jeong,

Affiliation Sheikh Zayed Center for Pediatric Surgical Innovation, Children’s National Health System, Washington, DC, United States of America
⨯
Annie Colberg-Poley,

Affiliation Center for Genetic Medicine Research, Children’s National Health System, Washington, DC, United States of America
⨯
Mary C. Rose,

Affiliation Center for Genetic Medicine Research, Children’s National Health System, Washington, DC, United States of America
⨯
Karuna C. Panchapakesan,

Affiliation Center for Genetic Medicine Research, Children’s National Health System, Washington, DC, United States of America
⨯
Joe C. Devaney,

Affiliation Center for Genetic Medicine Research, Children’s National Health System, Washington, DC, United States of America
⨯
Marcos Perez-Losada,

Affiliation Center for Genetic Medicine Research, Children’s National Health System, Washington, DC, United States of America
⨯
Diego Preciado

* E-mail: dpreciad@cnmc.org

Affiliations Sheikh Zayed Center for Pediatric Surgical Innovation, Children’s National Health System, Washington, DC, United States of America, Division of Pediatric Otolaryngology, Children’s National Health System, Washington, DC, United States of America
⨯

Proteomic Characterization of Middle Ear Fluid Confirms Neutrophil Extracellular Traps as a Predominant Innate Immune Response in Chronic Otitis Media

Stephanie Val,
Marian Poley,
Kristy Brown,
Rachel Choi,
Stephanie Jeong,
Annie Colberg-Poley,
Mary C. Rose,
Karuna C. Panchapakesan,
Joe C. Devaney,
Marcos Perez-Losada

Published: April 14, 2016
https://doi.org/10.1371/journal.pone.0152865

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Neutrophils
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Middle ear
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Serum proteins
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Mucin
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Histones
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Proteomics
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