Building a Robust Tumor Profiling Program: Synergy between Next-Generation Sequencing and Targeted Single-Gene Testing

Matthew C. Hiemenz; Stephan Kadauke; David B. Lieberman; David B. Roth; Jianhua Zhao; Christopher D. Watt; Robert D. Daber; Jennifer J. D. Morrissette

doi:10.1371/journal.pone.0152851

Loading metrics

Open Access

Peer-reviewed

Research Article

Building a Robust Tumor Profiling Program: Synergy between Next-Generation Sequencing and Targeted Single-Gene Testing

Matthew C. Hiemenz ,

Contributed equally to this work with: Matthew C. Hiemenz, Stephan Kadauke

Current address: BioReference Laboratories, Elmwood Park, New Jersey, United States of America

Affiliation Center for Personalized Diagnostics, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Stephan Kadauke ,

Contributed equally to this work with: Matthew C. Hiemenz, Stephan Kadauke

Current address: Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Affiliation Medical Scientist Training Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
David B. Lieberman,

Affiliation Center for Personalized Diagnostics, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
David B. Roth,

Affiliation Center for Personalized Diagnostics, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Jianhua Zhao,

Affiliation Center for Personalized Diagnostics, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Christopher D. Watt,

Affiliation Center for Personalized Diagnostics, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Robert D. Daber ,

Current address: BioReference Laboratories, Elmwood Park, New Jersey, United States of America

¶‡ These authors also contributed equally to this work

Affiliation Center for Personalized Diagnostics, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Jennifer J. D. Morrissette

* E-mail: Jennifer.Morrissette@uphs.upenn.edu

¶‡ These authors also contributed equally to this work

Affiliation Center for Personalized Diagnostics, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Building a Robust Tumor Profiling Program: Synergy between Next-Generation Sequencing and Targeted Single-Gene Testing

Matthew C. Hiemenz,
Stephan Kadauke,
David B. Lieberman,
David B. Roth,
Jianhua Zhao,
Christopher D. Watt,
Robert D. Daber,
Jennifer J. D. Morrissette

Published: April 4, 2016
https://doi.org/10.1371/journal.pone.0152851

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Next-generation sequencing
Is the Subject Area "Next-generation sequencing" applicable to this article?

Thanks for your feedback.
Lung and intrathoracic tumors
Is the Subject Area "Lung and intrathoracic tumors" applicable to this article?

Thanks for your feedback.
Mutation detection
Is the Subject Area "Mutation detection" applicable to this article?

Thanks for your feedback.
Point mutation
Is the Subject Area "Point mutation" applicable to this article?

Thanks for your feedback.
Hematologic cancers and related disorders
Is the Subject Area "Hematologic cancers and related disorders" applicable to this article?

Thanks for your feedback.
Mutation
Is the Subject Area "Mutation" applicable to this article?

Thanks for your feedback.
Malignant tumors
Is the Subject Area "Malignant tumors" applicable to this article?

Thanks for your feedback.
Non-small cell lung cancer
Is the Subject Area "Non-small cell lung cancer" applicable to this article?

Thanks for your feedback.