Cardiac Glycosides Activate the Tumor Suppressor and Viral Restriction Factor Promyelocytic Leukemia Protein (PML)

Snezana Milutinovic; Susanne Heynen-Genel; Elizabeth Chao; Antimone Dewing; Ricardo Solano; Loribelle Milan; Nikki Barron; Min He; Paul W. Diaz; Shu-ichi Matsuzawa; John C. Reed; Christian A. Hassig

doi:10.1371/journal.pone.0152692

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Open Access

Peer-reviewed

Research Article

Cardiac Glycosides Activate the Tumor Suppressor and Viral Restriction Factor Promyelocytic Leukemia Protein (PML)

Snezana Milutinovic,

Affiliation Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, United States of America
⨯
Susanne Heynen-Genel,

Affiliation Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, United States of America
⨯
Elizabeth Chao,

Affiliation Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, United States of America
⨯
Antimone Dewing,

Affiliation Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, United States of America
⨯
Ricardo Solano,

Affiliation Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, United States of America
⨯
Loribelle Milan,

Affiliation Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, United States of America
⨯
Nikki Barron,

Affiliation Bemer USA, LLC, Carlsbad, CA, United States of America
⨯
Min He,

Affiliation National Cancer Institute (NCI), Bethesda, MD, United States of America
⨯
Paul W. Diaz,

Affiliation P.William Diaz, Pharmaceutical Consulting, Riverside, CA, United States of America
⨯
Shu-ichi Matsuzawa,

Affiliation Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, United States of America
⨯
John C. Reed,

Current address: Roche, Grenzacherstrasse 124, 4070 Basel, Switzerland

Affiliation Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, United States of America
⨯
Christian A. Hassig

* E-mail: chassig@sbpdiscovery.org

Affiliation Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, United States of America
⨯

Cardiac Glycosides Activate the Tumor Suppressor and Viral Restriction Factor Promyelocytic Leukemia Protein (PML)

Snezana Milutinovic,
Susanne Heynen-Genel,
Elizabeth Chao,
Antimone Dewing,
Ricardo Solano,
Loribelle Milan,
Nikki Barron,
Min He,
Paul W. Diaz,
Shu-ichi Matsuzawa

Published: March 31, 2016
https://doi.org/10.1371/journal.pone.0152692

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