mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy

Manabu Taneike; Kazuhiko Nishida; Shigemiki Omiya; Elham Zarrinpashneh; Tomofumi Misaka; Rika Kitazume-Taneike; Ruth Austin; Minoru Takaoka; Osamu Yamaguchi; Michael J. Gambello; Ajay M. Shah; Kinya Otsu

doi:10.1371/journal.pone.0152628

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Peer-reviewed

Research Article

mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy

Manabu Taneike,

Affiliation Cardiovascular Division, King’s College London British Heart Foundation Centre of Excellence, London, United Kingdom
⨯
Kazuhiko Nishida,

Affiliation Cardiovascular Division, King’s College London British Heart Foundation Centre of Excellence, London, United Kingdom
⨯
Shigemiki Omiya,

Affiliation Cardiovascular Division, King’s College London British Heart Foundation Centre of Excellence, London, United Kingdom
⨯
Elham Zarrinpashneh,

Affiliation Cardiovascular Division, King’s College London British Heart Foundation Centre of Excellence, London, United Kingdom
⨯
Tomofumi Misaka,

Affiliation Cardiovascular Division, King’s College London British Heart Foundation Centre of Excellence, London, United Kingdom
⨯
Rika Kitazume-Taneike,

Affiliation Cardiovascular Division, King’s College London British Heart Foundation Centre of Excellence, London, United Kingdom
⨯
Ruth Austin,

Affiliation Cardiovascular Division, King’s College London British Heart Foundation Centre of Excellence, London, United Kingdom
⨯
Minoru Takaoka,

Affiliation Cardiovascular Division, King’s College London British Heart Foundation Centre of Excellence, London, United Kingdom
⨯
Osamu Yamaguchi,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
⨯
Michael J. Gambello,

Affiliation Division of Medical Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Ajay M. Shah,

Affiliation Cardiovascular Division, King’s College London British Heart Foundation Centre of Excellence, London, United Kingdom
⨯
Kinya Otsu

* E-mail: kinya.otsu@kcl.ac.uk

Affiliation Cardiovascular Division, King’s College London British Heart Foundation Centre of Excellence, London, United Kingdom
⨯

mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy

Manabu Taneike,
Kazuhiko Nishida,
Shigemiki Omiya,
Elham Zarrinpashneh,
Tomofumi Misaka,
Rika Kitazume-Taneike,
Ruth Austin,
Minoru Takaoka,
Osamu Yamaguchi,
Michael J. Gambello

Published: March 29, 2016
https://doi.org/10.1371/journal.pone.0152628

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Heart
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Autophagic cell death
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