Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer

Robert J. Cardnell; Ying Feng; Seema Mukherjee; Lixia Diao; Pan Tong; C. Allison Stewart; Fatemeh Masrorpour; YouHong Fan; Monique Nilsson; Yuqiao Shen; John V. Heymach; Jing Wang; Lauren A. Byers

doi:10.1371/journal.pone.0152584

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Open Access

Peer-reviewed

Research Article

Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer

Robert J. Cardnell ,

Contributed equally to this work with: Robert J. Cardnell, Ying Feng

Affiliation Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Ying Feng ,

Contributed equally to this work with: Robert J. Cardnell, Ying Feng

Affiliation Biomarin Pharmaceutical Inc., Novato, California, United States of America
⨯
Seema Mukherjee,

Affiliation Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Lixia Diao,

Affiliation Departmant of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Pan Tong,

Affiliation Departmant of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
C. Allison Stewart,

Affiliation Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Fatemeh Masrorpour,

Affiliation Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
YouHong Fan,

Affiliation Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Monique Nilsson,

Affiliation Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Yuqiao Shen,

Affiliation Biomarin Pharmaceutical Inc., Novato, California, United States of America
⨯
John V. Heymach,

Affiliation Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Jing Wang,

Affiliation Departmant of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Lauren A. Byers

* E-mail: lbyers@mdanderson.org

Affiliation Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯

Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer

Robert J. Cardnell,
Ying Feng,
Seema Mukherjee,
Lixia Diao,
Pan Tong,
C. Allison Stewart,
Fatemeh Masrorpour,
YouHong Fan,
Monique Nilsson,
Yuqiao Shen

Published: April 7, 2016
https://doi.org/10.1371/journal.pone.0152584

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