Spatio-Temporal Patterns of Demyelination and Remyelination in the Cuprizone Mouse Model

Ian Tagge; Audrey O’Connor; Priya Chaudhary; Jim Pollaro; Yosef Berlow; Megan Chalupsky; Dennis Bourdette; Randy Woltjer; Mac Johnson; William Rooney

doi:10.1371/journal.pone.0152480

Loading metrics

Open Access

Peer-reviewed

Research Article

Spatio-Temporal Patterns of Demyelination and Remyelination in the Cuprizone Mouse Model

Ian Tagge ,

* E-mail: taggei@ohsu.edu (IT); rooneyw@ohsu.edu (WR)

Affiliations Advanced Imaging Research Center, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States of America, Biomedical Engineering, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States of America
⨯
Audrey O’Connor,

Affiliation Advanced Imaging Research Center, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States of America
⨯
Priya Chaudhary,

Affiliation Neurology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States of America
⨯
Jim Pollaro,

Affiliation Advanced Imaging Research Center, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States of America
⨯
Yosef Berlow,

Affiliation Advanced Imaging Research Center, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States of America
⨯
Megan Chalupsky,

Affiliation Pathology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States of America
⨯
Dennis Bourdette,

Affiliations Neurology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States of America, Portland VA Medical Center, 3710 SW US Veterans Hospital Rd, Portland, OR 97239, United States of America
⨯
Randy Woltjer,

Affiliation Pathology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States of America
⨯
Mac Johnson,

Affiliation Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, MA 02210, United States of America
⨯
William Rooney

* E-mail: taggei@ohsu.edu (IT); rooneyw@ohsu.edu (WR)

Affiliations Advanced Imaging Research Center, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States of America, Biomedical Engineering, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States of America, Neurology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States of America
⨯

Spatio-Temporal Patterns of Demyelination and Remyelination in the Cuprizone Mouse Model

Ian Tagge,
Audrey O’Connor,
Priya Chaudhary,
Jim Pollaro,
Yosef Berlow,
Megan Chalupsky,
Dennis Bourdette,
Randy Woltjer,
Mac Johnson,
William Rooney

Published: April 7, 2016
https://doi.org/10.1371/journal.pone.0152480

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Magnetic resonance imaging
Is the Subject Area "Magnetic resonance imaging" applicable to this article?

Thanks for your feedback.
Histology
Is the Subject Area "Histology" applicable to this article?

Thanks for your feedback.
Corpus callosum
Is the Subject Area "Corpus callosum" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Central nervous system
Is the Subject Area "Central nervous system" applicable to this article?

Thanks for your feedback.
Astrocytes
Is the Subject Area "Astrocytes" applicable to this article?

Thanks for your feedback.
Brain damage
Is the Subject Area "Brain damage" applicable to this article?

Thanks for your feedback.