Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

• Aristos J. Alexandrou ,

  Contributed equally to this work with: Aristos J. Alexandrou, Adam R. Brown, Mark L. Chapman

  Affiliation Pfizer Neusentis, The Portway Buiding, Granta Park, Great Abington, Cambridge, CB21 6GS, United Kingdom

  ⨯
• Adam R. Brown ,

  Contributed equally to this work with: Aristos J. Alexandrou, Adam R. Brown, Mark L. Chapman

  Affiliation Pfizer Neusentis, The Portway Buiding, Granta Park, Great Abington, Cambridge, CB21 6GS, United Kingdom

  ⨯
• Mark L. Chapman ,

  Contributed equally to this work with: Aristos J. Alexandrou, Adam R. Brown, Mark L. Chapman

  Current address: Icagen, 4222 Emperor Boulevard, Durham, North Carolina, 27703, United States of America

  Affiliation Pfizer Neusentis, 4222 Emperor Boulevard, Durham, North Carolina, 27703, United States of America

  ⨯
• Mark Estacion,

  Affiliation Center for Neuroscience & Regeneration Research, Yale Medical School and Veterans Affairs Hospital, West Haven, CT, 06516, United States of America

  ⨯
• Jamie Turner,

  Affiliation Pfizer Neusentis, The Portway Buiding, Granta Park, Great Abington, Cambridge, CB21 6GS, United Kingdom

  ⨯
• Malgorzata A. Mis,

  Current address: School of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, United Kingdom

  Affiliation Pfizer Neusentis, The Portway Buiding, Granta Park, Great Abington, Cambridge, CB21 6GS, United Kingdom

  ⨯
• Anna Wilbrey,

  Affiliation Pfizer Neusentis, The Portway Buiding, Granta Park, Great Abington, Cambridge, CB21 6GS, United Kingdom

  ⨯
• Elizabeth C. Payne,

  Affiliation Pfizer Neusentis, The Portway Buiding, Granta Park, Great Abington, Cambridge, CB21 6GS, United Kingdom

  ⨯
• Alex Gutteridge,

  Affiliation Pfizer Neusentis, The Portway Buiding, Granta Park, Great Abington, Cambridge, CB21 6GS, United Kingdom

  ⨯
• Peter J. Cox,

  Affiliation Pfizer Neusentis, The Portway Buiding, Granta Park, Great Abington, Cambridge, CB21 6GS, United Kingdom

  ⨯
• Rachel Doyle,

  Current address: Tetrad Discovery Ltd Innovation House Discovery Park, Ramsgate Road, Sandwich, Kent, CT13 9ND, United Kingdom

  Affiliation Pfizer Global R&D, Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom

  ⨯
• David Printzenhoff,

  Current address: Icagen, 4222 Emperor Boulevard, Durham, North Carolina, 27703, United States of America

  Affiliation Pfizer Neusentis, 4222 Emperor Boulevard, Durham, North Carolina, 27703, United States of America

  ⨯
• Zhixin Lin,

  Current address: Icagen, 4222 Emperor Boulevard, Durham, North Carolina, 27703, United States of America

  Affiliation Pfizer Neusentis, 4222 Emperor Boulevard, Durham, North Carolina, 27703, United States of America

  ⨯
• Brian E. Marron,

  Current address: Icagen, 4222 Emperor Boulevard, Durham, North Carolina, 27703, United States of America

  Affiliation Pfizer Neusentis, 4222 Emperor Boulevard, Durham, North Carolina, 27703, United States of America

  ⨯
• Christopher West,

  Current address: Icagen, 4222 Emperor Boulevard, Durham, North Carolina, 27703, United States of America

  Affiliation Pfizer Neusentis, 4222 Emperor Boulevard, Durham, North Carolina, 27703, United States of America

  ⨯
• Nigel A. Swain,

  Affiliation Worldwide Medicinal Chemistry, Pfizer Neusentis, The Portway Building, Granta Park, Great Abington, Cambridge, CB21 6GS, United Kingdom

  ⨯
• R. Ian Storer,

  Affiliation Worldwide Medicinal Chemistry, Pfizer Neusentis, The Portway Building, Granta Park, Great Abington, Cambridge, CB21 6GS, United Kingdom

  ⨯
• Paul A. Stupple,

  Current address: Monash Institute of Pharmaceutical Sciences, Monash University (Parkville campus), 381 Royal Parade, Parkville, VIC, 3052, Australia

  Affiliation Worldwide Medicinal Chemistry, Pfizer Neusentis, The Portway Building, Granta Park, Great Abington, Cambridge, CB21 6GS, United Kingdom

  ⨯
• Neil A. Castle,

  Current address: Icagen, 4222 Emperor Boulevard, Durham, North Carolina, 27703, United States of America

  Affiliation Pfizer Neusentis, 4222 Emperor Boulevard, Durham, North Carolina, 27703, United States of America

  ⨯
• James A. Hounshell,

  Affiliation Dept. Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, 22911, United States of America

  ⨯
• Mirko Rivara,

  Current address: Dipartimento di Farmacia, Universita degli Studi di Parma, Parma, Italy

  Affiliation Dept. Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, 22911, United States of America

  ⨯
• Andrew Randall,

  Affiliation Medical School, Hatherly Building, University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, United Kingdom

  ⨯
• Sulayman D. Dib-Hajj,

  Affiliation Center for Neuroscience & Regeneration Research, Yale Medical School and Veterans Affairs Hospital, West Haven, CT, 06516, United States of America

  ⨯
• Douglas Krafte,

  Current address: Icagen, 4222 Emperor Boulevard, Durham, North Carolina, 27703, United States of America

  Affiliation Pfizer Neusentis, 4222 Emperor Boulevard, Durham, North Carolina, 27703, United States of America

  ⨯
• Stephen G. Waxman,

  Affiliation Center for Neuroscience & Regeneration Research, Yale Medical School and Veterans Affairs Hospital, West Haven, CT, 06516, United States of America

  ⨯
• Manoj K. Patel,

  Affiliation Dept. Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, 22911, United States of America

  ⨯
• Richard P. Butt ,

  * E-mail: Edward.Stevens@pfizer.com (EBS); Richard.Butt@pfizer.com (RPB)

  Affiliation Pfizer Neusentis, The Portway Buiding, Granta Park, Great Abington, Cambridge, CB21 6GS, United Kingdom

  ⨯
•  [ ... ],
• Edward B. Stevens

  * E-mail: Edward.Stevens@pfizer.com (EBS); Richard.Butt@pfizer.com (RPB)

  Affiliation Pfizer Neusentis, The Portway Buiding, Granta Park, Great Abington, Cambridge, CB21 6GS, United Kingdom

  ⨯
• [ view all ]
• [ view less ]