Effects of Single Low Dose of Dexamethasone before Noncardiac and Nonneurologic Surgery and General Anesthesia on Postoperative Cognitive Dysfunction—A Phase III Double Blind, Randomized Clinical Trial

• Livia Stocco Sanches Valentin ,

  * E-mail: lssv@usp.br

  Affiliation Department of Anesthesia, LIM 8 –Laboratory of Anesthesiology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil

  http://orcid.org/0000-0003-1520-5570

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• Valeria Fontenelle Angelim Pereira,

  Affiliation Department of Anesthesia, LIM 8 –Laboratory of Anesthesiology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil

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• Ricardo S. Pietrobon,

  Affiliation Department of Surgery, Duke University Health System, Durham, North Carolina, United States of America

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• Andre P. Schmidt,

  Affiliations Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil, Department of Anesthesia and Perioperative Medicine, Hospital de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil

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• Jean P. Oses,

  Affiliation Center of Sciences of the Life and Health, Universidade Católica de Pelotas, Pelotas, Rio Grande do Sul, Brazil

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• Luis V. Portela,

  Affiliation Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

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• Diogo O. Souza,

  Affiliation Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

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• João Ricardo Nickenig Vissoci,

  Current address: Department of Medicine, Faculdade Ingá, Maringá, Paraná, Brazil

  Affiliation Department of Surgery, Duke University Health System, Durham, North Carolina, United States of America

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• Vinicius Fernando da Luz,

  Affiliation Department of Anesthesia, LIM 8 –Laboratory of Anesthesiology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil

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• Leticia Maria de Araujo de Souza Trintoni,

  Affiliation Department of Anesthesia, LIM 8 –Laboratory of Anesthesiology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil

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• Karen C. Nielsen,

  Affiliation Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, United States of America

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• Maria José Carvalho Carmona

  Affiliation Department of Anesthesia, LIM 8 –Laboratory of Anesthesiology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil

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