Sulforaphane Suppresses Hepatitis C Virus Replication by Up-Regulating Heme Oxygenase-1 Expression through PI3K/Nrf2 Pathway

• Jung-Sheng Yu ,

  Contributed equally to this work with: Jung-Sheng Yu, Wei-Chun Chen

  Affiliations Department of Chinese Medicine, Chi Mei Medical Center, Tainan, 71004, Taiwan, Graduate Institute of Integrated Medicine, China Medical University, Taichung, 40402, Taiwan

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• Wei-Chun Chen ,

  Contributed equally to this work with: Jung-Sheng Yu, Wei-Chun Chen

  Affiliation Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

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• Chin-Kai Tseng,

  Affiliations Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Center of Infectious Disease and Signaling Research, College of Medicine, National Cheng Kung University, Tainan, Taiwan

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• Chun-Kuang Lin,

  Affiliation Doctoral Degree Program in Marine Biotechnology, College of Marine Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan

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• Yao-Chin Hsu,

  Affiliation Department of Chinese Medicine, Chi Mei Medical Center, Tainan, 71004, Taiwan

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• Yen-Hsu Chen ,

  * E-mail: jclee@kmu.edu.tw (J-CL); infchen@gmail.com (Y-HC)

  Affiliations Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, School of Medicine, Graduate Institute of Medicine, Sepsis Research Center, Center for Dengue Fever Control and Research, Kaohsiung Medical University, Kaohsiung, Taiwan, Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, HsinChu, Taiwan, Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan

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• Jin-Ching Lee

  * E-mail: jclee@kmu.edu.tw (J-CL); infchen@gmail.com (Y-HC)

  Affiliations Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan, Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Research Center for Natural Products and Drug Development, Kaohsiung Medical University, Kaohsiung, Taiwan

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