Imaging Mass Spectrometry Reveals Acyl-Chain- and Region-Specific Sphingolipid Metabolism in the Kidneys of Sphingomyelin Synthase 2-Deficient Mice

Masayuki Sugimoto; Masato Wakabayashi; Yoichi Shimizu; Takeshi Yoshioka; Kenichi Higashino; Yoshito Numata; Tomohiko Okuda; Songji Zhao; Shota Sakai; Yasuyuki Igarashi; Yuji Kuge

doi:10.1371/journal.pone.0152191

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Peer-reviewed

Research Article

Imaging Mass Spectrometry Reveals Acyl-Chain- and Region-Specific Sphingolipid Metabolism in the Kidneys of Sphingomyelin Synthase 2-Deficient Mice

Masayuki Sugimoto,

Affiliations Department of Integrated Molecular Imaging, Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Shionogi Innovation Center for Drug Discovery, Discovery Research Laboratory for Innovative Frontier Medicines, Shionogi & Co., Ltd., Sapporo, Japan
⨯
Masato Wakabayashi,

Affiliation Shionogi Innovation Center for Drug Discovery, Discovery Research Laboratory for Innovative Frontier Medicines, Shionogi & Co., Ltd., Sapporo, Japan
⨯
Yoichi Shimizu,

Affiliations Central Institute of Isotope Science, Hokkaido University, Sapporo, Japan, Laboratory of Bioanalysis and Molecular Imaging, Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, Japan
⨯
Takeshi Yoshioka,

Affiliation Shionogi Innovation Center for Drug Discovery, Discovery Research Laboratory for Innovative Frontier Medicines, Shionogi & Co., Ltd., Sapporo, Japan
⨯
Kenichi Higashino,

Affiliation Shionogi Innovation Center for Drug Discovery, Discovery Research Laboratory for Innovative Frontier Medicines, Shionogi & Co., Ltd., Sapporo, Japan
⨯
Yoshito Numata,

Affiliation Shionogi Innovation Center for Drug Discovery, Discovery Research Laboratory for Innovative Frontier Medicines, Shionogi & Co., Ltd., Sapporo, Japan
⨯
Tomohiko Okuda,

Affiliation Drug Discovery Technologies, Discovery Research Laboratory for Core Therapeutic Areas, Shionogi & Co., Ltd., Toyonaka, Japan
⨯
Songji Zhao,

Affiliation Department of Tracer Kinetics & Bioanalysis, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
⨯
Shota Sakai,

Affiliation Department of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan
⨯
Yasuyuki Igarashi,

Affiliation Department of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan
⨯
Yuji Kuge

* E-mail: kuge@ric.hokudai.ac.jp

Affiliations Department of Integrated Molecular Imaging, Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Central Institute of Isotope Science, Hokkaido University, Sapporo, Japan
⨯

Imaging Mass Spectrometry Reveals Acyl-Chain- and Region-Specific Sphingolipid Metabolism in the Kidneys of Sphingomyelin Synthase 2-Deficient Mice

Masayuki Sugimoto,
Masato Wakabayashi,
Yoichi Shimizu,
Takeshi Yoshioka,
Kenichi Higashino,
Yoshito Numata,
Tomohiko Okuda,
Songji Zhao,
Shota Sakai,
Yasuyuki Igarashi

Published: March 24, 2016
https://doi.org/10.1371/journal.pone.0152191

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