Complement Factor H-Related Protein 3 Serum Levels Are Low Compared to Factor H and Mainly Determined by Gene Copy Number Variation in CFHR3

Richard B. Pouw; Mieke C. Brouwer; Judy Geissler; Laurens V. van Herpen; Sacha S. Zeerleder; Walter A. Wuillemin; Diana Wouters; Taco W. Kuijpers

doi:10.1371/journal.pone.0152164

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Peer-reviewed

Research Article

Complement Factor H-Related Protein 3 Serum Levels Are Low Compared to Factor H and Mainly Determined by Gene Copy Number Variation in CFHR3

Richard B. Pouw,

Affiliations Department of Immunopathology, Sanquin Research and Landsteiner laboratory of the Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands, Department of Pediatric Hematology, Immunology & Infectious Diseases, Emma Children’s Hospital, Academic Medical Center, Amsterdam, the Netherlands
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Mieke C. Brouwer,

Affiliation Department of Immunopathology, Sanquin Research and Landsteiner laboratory of the Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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Judy Geissler,

Affiliation Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory of the Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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Laurens V. van Herpen,

Affiliation Department of Immunopathology, Sanquin Research and Landsteiner laboratory of the Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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Sacha S. Zeerleder,

Affiliation Department of Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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Walter A. Wuillemin,

Affiliation Division of Hematology and Central Hematology Laboratory, Luzerner Kantonsspital and University of Berne, Berne, Switzerland
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Diana Wouters ,

* E-mail: d.wouters@sanquin.nl

Affiliation Department of Immunopathology, Sanquin Research and Landsteiner laboratory of the Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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Taco W. Kuijpers

Affiliations Department of Pediatric Hematology, Immunology & Infectious Diseases, Emma Children’s Hospital, Academic Medical Center, Amsterdam, the Netherlands, Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory of the Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
⨯

Complement Factor H-Related Protein 3 Serum Levels Are Low Compared to Factor H and Mainly Determined by Gene Copy Number Variation in CFHR3

Richard B. Pouw,
Mieke C. Brouwer,
Judy Geissler,
Laurens V. van Herpen,
Sacha S. Zeerleder,
Walter A. Wuillemin,
Diana Wouters,
Taco W. Kuijpers

Published: March 23, 2016
https://doi.org/10.1371/journal.pone.0152164

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Enzyme-linked immunoassays
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Serum proteins
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Acute phase proteins
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Copy number variation
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