Selective Preference of Parallel DNA Triplexes Is Due to the Disruption of Hoogsteen Hydrogen Bonds Caused by the Severe Nonisostericity between the G*GC and T*AT Triplets

Open Access

Peer-reviewed

Research Article

Selective Preference of Parallel DNA Triplexes Is Due to the Disruption of Hoogsteen Hydrogen Bonds Caused by the Severe Nonisostericity between the GGC and TAT Triplets

Gunaseelan Goldsmith,

Affiliations Institute of Bioinformatics and Applied Biotechnology, Biotech Park, Electronics City Phase I, Bangalore, India, Manipal University, Manipal, India
⨯
Thenmalarchelvi Rathinavelan,

Current address: Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Telangana State, India

Affiliation Institute of Bioinformatics and Applied Biotechnology, Biotech Park, Electronics City Phase I, Bangalore, India
⨯
Narayanarao Yathindra

* E-mail: yathindra@ibab.ac.in

Affiliation Institute of Bioinformatics and Applied Biotechnology, Biotech Park, Electronics City Phase I, Bangalore, India
⨯

Hydrogen bonding
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Trinucleotide repeats
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Free energy
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Biochemical simulations
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Nucleic acids
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DNA structure
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DNA-RNA hybridization
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RNA structure
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