Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4α miR122 Pathway

Shengnan Wei; Ming Zhang; Yang Yu; Xiaoxin Lan; Fan Yao; Xin Yan; Li Chen; Grant M. Hatch

doi:10.1371/journal.pone.0152097

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Research Article

Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4α miR122 Pathway

Shengnan Wei ,

Contributed equally to this work with: Shengnan Wei, Ming Zhang

¶‡ These authors are co-first authors on this work.

Affiliation Department of Pharmacology, College of Basic Medical Sciences, School of Nursing, Jilin University, Changchun, Jilin, China
⨯
Ming Zhang ,

Contributed equally to this work with: Shengnan Wei, Ming Zhang

¶‡ These authors are co-first authors on this work.

Affiliations Department of Pharmacology, College of Basic Medical Sciences, School of Nursing, Jilin University, Changchun, Jilin, China, Department of Pharmacology & Therapeutics, Biochemistry and Medical Genetics, University of Manitoba, DREAM, Children’s Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada
⨯
Yang Yu,

Affiliation Department of Pharmacology, College of Basic Medical Sciences, School of Nursing, Jilin University, Changchun, Jilin, China
⨯
Xiaoxin Lan,

Affiliation Department of Pharmacology, College of Basic Medical Sciences, School of Nursing, Jilin University, Changchun, Jilin, China
⨯
Fan Yao,

Affiliation Department of Pharmacology, College of Basic Medical Sciences, School of Nursing, Jilin University, Changchun, Jilin, China
⨯
Xin Yan,

Affiliation Department of Pharmacology, College of Basic Medical Sciences, School of Nursing, Jilin University, Changchun, Jilin, China
⨯
Li Chen ,

* E-mail: chen_lab@163.com

Affiliation Department of Pharmacology, College of Basic Medical Sciences, School of Nursing, Jilin University, Changchun, Jilin, China
⨯
Grant M. Hatch

Affiliation Department of Pharmacology & Therapeutics, Biochemistry and Medical Genetics, University of Manitoba, DREAM, Children’s Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada
⨯

Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4α miR122 Pathway

Shengnan Wei,
Ming Zhang,
Yang Yu,
Xiaoxin Lan,
Fan Yao,
Xin Yan,
Li Chen,
Grant M. Hatch

Published: March 24, 2016
https://doi.org/10.1371/journal.pone.0152097

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