Notch Signaling Activates Stem Cell Properties of Müller Glia through Transcriptional Regulation and Skp2-mediated Degradation of p27Kip1

Carolina Beltrame Del Debbio; Qulsum Mir; Sowmya Parameswaran; Saumi Mathews; Xiaohuan Xia; Li Zheng; Andrew J. Neville; Iqbal Ahmad

doi:10.1371/journal.pone.0152025

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Open Access

Peer-reviewed

Research Article

Notch Signaling Activates Stem Cell Properties of Müller Glia through Transcriptional Regulation and Skp2-mediated Degradation of p27^Kip1

Carolina Beltrame Del Debbio ,

Contributed equally to this work with: Carolina Beltrame Del Debbio, Qulsum Mir

Current address: Department of Cell and Developmental Biology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil

Affiliation Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Qulsum Mir ,

Contributed equally to this work with: Carolina Beltrame Del Debbio, Qulsum Mir

Affiliation Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Sowmya Parameswaran,

Current address: Department of Radheshyam Kanoi Stem Cell Laboratory, Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India

Affiliation Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Saumi Mathews,

Affiliation Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Xiaohuan Xia,

Affiliation Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Li Zheng,

Affiliation Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Andrew J. Neville,

Affiliation Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Iqbal Ahmad

* E-mail: iahmad@unmc.edu

Affiliation Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯

Notch Signaling Activates Stem Cell Properties of Müller Glia through Transcriptional Regulation and Skp2-mediated Degradation of p27^Kip1

Carolina Beltrame Del Debbio,
Qulsum Mir,
Sowmya Parameswaran,
Saumi Mathews,
Xiaohuan Xia,
Li Zheng,
Andrew J. Neville,
Iqbal Ahmad

Published: March 24, 2016
https://doi.org/10.1371/journal.pone.0152025

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Neurospheres
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Lentivirus
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