An IRF5 Decoy Peptide Reduces Myocardial Inflammation and Fibrosis and Improves Endothelial Cell Function in Tight-Skin Mice

Dorothee Weihrauch; John G. Krolikowski; Deron W. Jones; Tahniyath Zaman; Omoshalewa Bamkole; Janine Struve; Savin Pillai; Paul S. Pagel; Nicole L. Lohr; Kirkwood A. Pritchard Jr

doi:10.1371/journal.pone.0151999

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Peer-reviewed

Research Article

An IRF5 Decoy Peptide Reduces Myocardial Inflammation and Fibrosis and Improves Endothelial Cell Function in Tight-Skin Mice

Dorothee Weihrauch ,

* E-mail: dorothee@mcw.edu

Affiliation Departments of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
John G. Krolikowski,

Affiliation Departments of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Deron W. Jones,

Affiliations Department of Surgery, Division of Pediatric Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Children’s Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Tahniyath Zaman,

Affiliations Department of Surgery, Division of Pediatric Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Children’s Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Omoshalewa Bamkole,

Affiliation Departments of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Janine Struve,

Affiliation Orthopedic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Savin Pillai,

Affiliation Departments of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Paul S. Pagel,

Affiliations Departments of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin, United States of America
⨯
Nicole L. Lohr,

Affiliation Department of Medicine, Division of Cardiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Kirkwood A. Pritchard Jr

Affiliations Department of Surgery, Division of Pediatric Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Children’s Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯

An IRF5 Decoy Peptide Reduces Myocardial Inflammation and Fibrosis and Improves Endothelial Cell Function in Tight-Skin Mice

Dorothee Weihrauch,
John G. Krolikowski,
Deron W. Jones,
Tahniyath Zaman,
Omoshalewa Bamkole,
Janine Struve,
Savin Pillai,
Paul S. Pagel,
Nicole L. Lohr,
Kirkwood A. Pritchard Jr

Published: April 6, 2016
https://doi.org/10.1371/journal.pone.0151999

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