Entrapment of H1N1 Influenza Virus Derived Conserved Peptides in PLGA Nanoparticles Enhances T Cell Response and Vaccine Efficacy in Pigs

Jagadish Hiremath; Kyung-il Kang; Ming Xia; Mohamed Elaish; Basavaraj Binjawadagi; Kang Ouyang; Santosh Dhakal; Jesus Arcos; Jordi B. Torrelles; X. Jiang; Chang Won Lee; Gourapura J. Renukaradhya

doi:10.1371/journal.pone.0151922

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Peer-reviewed

Research Article

Entrapment of H1N1 Influenza Virus Derived Conserved Peptides in PLGA Nanoparticles Enhances T Cell Response and Vaccine Efficacy in Pigs

Jagadish Hiremath,

Affiliation Food Animal Health Research Program, Ohio Agricultural Research and Development Center, 1680 Madison Avenue, Wooster, Ohio, 44691, United States of America, and Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, 43210, United States of America
⨯
Kyung-il Kang,

Affiliation Food Animal Health Research Program, Ohio Agricultural Research and Development Center, 1680 Madison Avenue, Wooster, Ohio, 44691, United States of America, and Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, 43210, United States of America
⨯
Ming Xia,

Affiliation Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
Mohamed Elaish,

Affiliation Food Animal Health Research Program, Ohio Agricultural Research and Development Center, 1680 Madison Avenue, Wooster, Ohio, 44691, United States of America, and Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, 43210, United States of America
⨯
Basavaraj Binjawadagi,

Affiliation Food Animal Health Research Program, Ohio Agricultural Research and Development Center, 1680 Madison Avenue, Wooster, Ohio, 44691, United States of America, and Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, 43210, United States of America
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Kang Ouyang,

Affiliation Food Animal Health Research Program, Ohio Agricultural Research and Development Center, 1680 Madison Avenue, Wooster, Ohio, 44691, United States of America, and Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, 43210, United States of America
⨯
Santosh Dhakal,

Affiliation Food Animal Health Research Program, Ohio Agricultural Research and Development Center, 1680 Madison Avenue, Wooster, Ohio, 44691, United States of America, and Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, 43210, United States of America
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Jesus Arcos,

Affiliation Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, United States of America
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Jordi B. Torrelles,

Affiliation Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, United States of America
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X. Jiang,

Affiliation Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
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Chang Won Lee ,

* E-mail: gourapura.1@osu.edu (GJR); lee.2854@osu.edu (CWL)

Affiliation Food Animal Health Research Program, Ohio Agricultural Research and Development Center, 1680 Madison Avenue, Wooster, Ohio, 44691, United States of America, and Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, 43210, United States of America
⨯
Gourapura J. Renukaradhya

* E-mail: gourapura.1@osu.edu (GJR); lee.2854@osu.edu (CWL)

Affiliation Food Animal Health Research Program, Ohio Agricultural Research and Development Center, 1680 Madison Avenue, Wooster, Ohio, 44691, United States of America, and Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, 43210, United States of America
⨯

Entrapment of H1N1 Influenza Virus Derived Conserved Peptides in PLGA Nanoparticles Enhances T Cell Response and Vaccine Efficacy in Pigs

Jagadish Hiremath,
Kyung-il Kang,
Ming Xia,
Mohamed Elaish,
Basavaraj Binjawadagi,
Kang Ouyang,
Santosh Dhakal,
Jesus Arcos,
Jordi B. Torrelles,
X. Jiang

Published: April 19, 2016
https://doi.org/10.1371/journal.pone.0151922

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