Charge Variants of an Avastin Biosimilar Isolation, Characterization, In Vitro Properties and Pharmacokinetics in Rat

Yan-Yan Zhao; Ning Wang; Wan-Hui Liu; Wen-Jie Tao; Li-Li Liu; Zhen-Duo Shen

doi:10.1371/journal.pone.0151874

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Peer-reviewed

Research Article

Charge Variants of an Avastin Biosimilar Isolation, Characterization, In Vitro Properties and Pharmacokinetics in Rat

Yan-Yan Zhao ,

Contributed equally to this work with: Yan-Yan Zhao, Ning Wang

Affiliations School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, P.R. China, State Key Laboratory of Long-acting and Targeting Drug Delivery System, Luye Pharma Group Ltd., Yantai, 264005, P.R. China
⨯
Ning Wang ,

Contributed equally to this work with: Yan-Yan Zhao, Ning Wang

Affiliation School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, P.R. China
⨯
Wan-Hui Liu ,

* E-mail: wanhuiliu@ytu.edu.cn

Affiliations School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, P.R. China, State Key Laboratory of Long-acting and Targeting Drug Delivery System, Luye Pharma Group Ltd., Yantai, 264005, P.R. China
⨯
Wen-Jie Tao,

Affiliation State Key Laboratory of Long-acting and Targeting Drug Delivery System, Luye Pharma Group Ltd., Yantai, 264005, P.R. China
⨯
Li-Li Liu,

Affiliation State Key Laboratory of Long-acting and Targeting Drug Delivery System, Luye Pharma Group Ltd., Yantai, 264005, P.R. China
⨯
Zhen-Duo Shen

Affiliation State Key Laboratory of Long-acting and Targeting Drug Delivery System, Luye Pharma Group Ltd., Yantai, 264005, P.R. China
⨯

Charge Variants of an Avastin Biosimilar Isolation, Characterization, In Vitro Properties and Pharmacokinetics in Rat

Yan-Yan Zhao,
Ning Wang,
Wan-Hui Liu,
Wen-Jie Tao,
Li-Li Liu,
Zhen-Duo Shen

Published: March 17, 2016
https://doi.org/10.1371/journal.pone.0151874

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