Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade

Fenqing Shang; Jiao Zhang; Zhao Li; Jin Zhang; Yanjun Yin; Yaqiong Wang; Traci L. Marin; Brendan Gongol; Han Xiao; You-yi Zhang; Zhen Chen; John Y-J Shyy; Ting Lei

doi:10.1371/journal.pone.0151845

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Open Access

Peer-reviewed

Research Article

Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade

Fenqing Shang,

Affiliation Cardiovascular Research Center, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi'an, China
⨯
Jiao Zhang,

Affiliations Cardiovascular Research Center, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi'an, China, Department of Cardiology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
⨯
Zhao Li,

Affiliation Cardiovascular Research Center, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi'an, China
⨯
Jin Zhang,

Affiliation Cardiovascular Research Center, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi'an, China
⨯
Yanjun Yin,

Affiliation Cardiovascular Research Center, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi'an, China
⨯
Yaqiong Wang,

Affiliation Cardiovascular Research Center, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi'an, China
⨯
Traci L. Marin,

Affiliation Departments of Cardiopulmonary Science and Anatomy, Schools of Allied Health and Medicine, Loma Linda University, Loma Linda, CA, United States of America
⨯
Brendan Gongol,

Affiliation Departments of Cardiopulmonary Science and Anatomy, Schools of Allied Health and Medicine, Loma Linda University, Loma Linda, CA, United States of America
⨯
Han Xiao,

Affiliation Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China
⨯
You-yi Zhang,

Affiliation Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China
⨯
Zhen Chen,

Affiliation Department of Medicine, School of Medicine, University of California, San Diego, La Jolla CA, United States of America
⨯
John Y-J Shyy,

Affiliation Cardiovascular Research Center, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi'an, China
⨯
Ting Lei

* E-mail: leiting@mail.xjtu.edu.cn

Affiliations Cardiovascular Research Center, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi'an, China, Department of Pathology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi'an, China
⨯

Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade

Fenqing Shang,
Jiao Zhang,
Zhao Li,
Jin Zhang,
Yanjun Yin,
Yaqiong Wang,
Traci L. Marin,
Brendan Gongol,
Han Xiao,
You-yi Zhang

Published: March 17, 2016
https://doi.org/10.1371/journal.pone.0151845

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