Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice

Leola N. Chow; Petra Schreiner; Betina Y. Y. Ng; Bernard Lo; Michael R. Hughes; R. Wilder Scott; Vionarica Gusti; Samantha Lecour; Eric Simonson; Irina Manisali; Ingrid Barta; Kelly M. McNagny; Jason Crawford; Murray Webb; T. Michael Underhill

doi:10.1371/journal.pone.0151765

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Open Access

Peer-reviewed

Research Article

Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice

Leola N. Chow ,

* E-mail: lchow@cdrd.ca (LNC); tunderhi@brc.ubc.ca (TMU)

Affiliation The Centre for Drug Research and Development, Vancouver, British Columbia, Canada
⨯
Petra Schreiner,

Affiliation The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Betina Y. Y. Ng,

Affiliation The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Bernard Lo,

Affiliation The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Michael R. Hughes,

Affiliation The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
⨯
R. Wilder Scott,

Affiliation The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Vionarica Gusti,

Affiliation The Centre for Drug Research and Development, Vancouver, British Columbia, Canada
⨯
Samantha Lecour,

Affiliation The Centre for Drug Research and Development, Vancouver, British Columbia, Canada
⨯
Eric Simonson,

Affiliation The Centre for Drug Research and Development, Vancouver, British Columbia, Canada
⨯
Irina Manisali,

Affiliation The Centre for Drug Research and Development, Vancouver, British Columbia, Canada
⨯
Ingrid Barta,

Affiliation The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Kelly M. McNagny,

Affiliation The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Jason Crawford,

Affiliation The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Murray Webb,

Affiliation The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
⨯
T. Michael Underhill

* E-mail: lchow@cdrd.ca (LNC); tunderhi@brc.ubc.ca (TMU)

Affiliation The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
⨯

Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice

Leola N. Chow,
Petra Schreiner,
Betina Y. Y. Ng,
Bernard Lo,
Michael R. Hughes,
R. Wilder Scott,
Vionarica Gusti,
Samantha Lecour,
Eric Simonson,
Irina Manisali

Published: March 21, 2016
https://doi.org/10.1371/journal.pone.0151765

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