Methylation Microarray Studies Highlight PDGFA Expression as a Factor in Biliary Atresia

Zenobia C. Cofer; Shuang Cui; Steven F. EauClaire; Cecilia Kim; John W. Tobias; Hakon Hakonarson; Kathleen M. Loomes; Randolph P. Matthews

doi:10.1371/journal.pone.0151521

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Research Article

Methylation Microarray Studies Highlight PDGFA Expression as a Factor in Biliary Atresia

Zenobia C. Cofer,

Affiliation Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, United States of America
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Shuang Cui,

Affiliation Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, United States of America
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Steven F. EauClaire,

Affiliation Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, United States of America
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Cecilia Kim,

Affiliation Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
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John W. Tobias,

Affiliation Penn Center for Biomedical Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Hakon Hakonarson,

Affiliations Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Kathleen M. Loomes ,

* E-mail: loomes@email.chop.edu

Affiliations Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Randolph P. Matthews

Current address: Merck Research Laboratories, 351 N. Sumneytown Pike, UG 4D-34, North Wales, Pennsylvania, United States of America

Affiliations Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Methylation Microarray Studies Highlight PDGFA Expression as a Factor in Biliary Atresia

Zenobia C. Cofer,
Shuang Cui,
Steven F. EauClaire,
Cecilia Kim,
John W. Tobias,
Hakon Hakonarson,
Kathleen M. Loomes,
Randolph P. Matthews

Published: March 24, 2016
https://doi.org/10.1371/journal.pone.0151521

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DNA methylation
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Hedgehog signaling
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Microarrays
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Larvae
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Liver transplantation
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