Geranylated 4-Phenylcoumarins Exhibit Anticancer Effects against Human Prostate Cancer Cells through Caspase-Independent Mechanism

Noor Shahirah Suparji; Gomathi Chan; Hani Sapili; Norhafiza M. Arshad; Lionel L. A. In; Khalijah Awang; Noor Hasima Nagoor

doi:10.1371/journal.pone.0151472

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Open Access

Peer-reviewed

Research Article

Geranylated 4-Phenylcoumarins Exhibit Anticancer Effects against Human Prostate Cancer Cells through Caspase-Independent Mechanism

Noor Shahirah Suparji,

Affiliation Institute of Biological Science (Genetics & Molecular Biology), Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
⨯
Gomathi Chan,

Affiliation Centre for Natural Product Research and Drug Discovery (CENAR), Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
⨯
Hani Sapili,

Affiliation Institute of Biological Science (Genetics & Molecular Biology), Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
⨯
Norhafiza M. Arshad,

Affiliations Institute of Biological Science (Genetics & Molecular Biology), Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia, Centre for Research in Biotechnology for Agriculture (CEBAR), University of Malaya, Kuala Lumpur, Malaysia
⨯
Lionel L. A. In,

Affiliations Institute of Biological Science (Genetics & Molecular Biology), Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia, Department of Biotechnology, Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia
⨯
Khalijah Awang,

Affiliation Centre for Natural Product Research and Drug Discovery (CENAR), Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
⨯
Noor Hasima Nagoor

* E-mail: hasima@um.edu.my

Affiliations Institute of Biological Science (Genetics & Molecular Biology), Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia, Centre for Research in Biotechnology for Agriculture (CEBAR), University of Malaya, Kuala Lumpur, Malaysia
⨯

Geranylated 4-Phenylcoumarins Exhibit Anticancer Effects against Human Prostate Cancer Cells through Caspase-Independent Mechanism

Noor Shahirah Suparji,
Gomathi Chan,
Hani Sapili,
Norhafiza M. Arshad,
Lionel L. A. In,
Khalijah Awang,
Noor Hasima Nagoor

Published: March 14, 2016
https://doi.org/10.1371/journal.pone.0151472

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