Oridonin Attenuates Synaptic Loss and Cognitive Deficits in an Aβ1–42-Induced Mouse Model of Alzheimer’s Disease

Sulei Wang; Linjie Yu; Hui Yang; Chaosheng Li; Zhen Hui; Yun Xu; Xiaolei Zhu

doi:10.1371/journal.pone.0151397

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Research Article

Oridonin Attenuates Synaptic Loss and Cognitive Deficits in an Aβ_1–42-Induced Mouse Model of Alzheimer’s Disease

Sulei Wang ,

Contributed equally to this work with: Sulei Wang, Linjie Yu

Affiliation Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, PR China
⨯
Linjie Yu ,

Contributed equally to this work with: Sulei Wang, Linjie Yu

Affiliation Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, PR China
⨯
Hui Yang,

Affiliation Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, PR China
⨯
Chaosheng Li,

Affiliation Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, PR China
⨯
Zhen Hui,

Affiliation Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, PR China
⨯
Yun Xu ,

* E-mail: xuyun20042001@aliyun.com (YX); zhuquelee@126.com (XLZ)

Affiliations Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, PR China, Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, PR China, Jiangsu Stroke Research Collaborative Group, Nanjing, PR China, Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, PR China, Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, PR China
⨯
Xiaolei Zhu

* E-mail: xuyun20042001@aliyun.com (YX); zhuquelee@126.com (XLZ)

Affiliation Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, PR China
⨯

Oridonin Attenuates Synaptic Loss and Cognitive Deficits in an Aβ_1–42-Induced Mouse Model of Alzheimer’s Disease

Sulei Wang,
Linjie Yu,
Hui Yang,
Chaosheng Li,
Zhen Hui,
Yun Xu,
Xiaolei Zhu

Published: March 14, 2016
https://doi.org/10.1371/journal.pone.0151397

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