Loss of ATP-Sensitive Potassium Channel Surface Expression in Heart Failure Underlies Dysregulation of Action Potential Duration and Myocardial Vulnerability to Injury

Zhan Gao; Ana Sierra; Zhiyong Zhu; Siva Rama Krishna Koganti; Ekaterina Subbotina; Ankit Maheshwari; Mark E. Anderson; Leonid V. Zingman; Denice M. Hodgson-Zingman

doi:10.1371/journal.pone.0151337

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Peer-reviewed

Research Article

Loss of ATP-Sensitive Potassium Channel Surface Expression in Heart Failure Underlies Dysregulation of Action Potential Duration and Myocardial Vulnerability to Injury

Zhan Gao,

Affiliation Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Ana Sierra,

Affiliation Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Zhiyong Zhu,

Affiliation Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Siva Rama Krishna Koganti,

Current address: Texas Tech University Health Sciences Center, Abilene, TX, USA

Affiliation Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Ekaterina Subbotina,

Affiliation Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Ankit Maheshwari,

Current address: University of Minnesota, Minneapolis, MN, USA

Affiliation Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Mark E. Anderson,

Current address: Johns Hopkins University, Baltimore, MD, USA

Affiliations Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America, François Abboud Cardiovascular Research Center, University of Iowa, Iowa City, Iowa, United States of America
⨯
Leonid V. Zingman ,

¶‡ Joint Senior Authors.

Affiliations Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America, François Abboud Cardiovascular Research Center, University of Iowa, Iowa City, Iowa, United States of America, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa, United States of America, Veterans Affairs Medical Center, Iowa City, Iowa, United States of America
⨯
Denice M. Hodgson-Zingman

* E-mail: denice-zingman@uiowa.edu

¶‡ Joint Senior Authors.

Affiliations Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America, François Abboud Cardiovascular Research Center, University of Iowa, Iowa City, Iowa, United States of America
⨯

Loss of ATP-Sensitive Potassium Channel Surface Expression in Heart Failure Underlies Dysregulation of Action Potential Duration and Myocardial Vulnerability to Injury

Zhan Gao,
Ana Sierra,
Zhiyong Zhu,
Siva Rama Krishna Koganti,
Ekaterina Subbotina,
Ankit Maheshwari,
Mark E. Anderson,
Leonid V. Zingman,
Denice M. Hodgson-Zingman

Published: March 10, 2016
https://doi.org/10.1371/journal.pone.0151337

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