Principal Component Analysis of Multimodal Neuromelanin MRI and Dopamine Transporter PET Data Provides a Specific Metric for the Nigral Dopaminergic Neuronal Density

• Hiroshi Kawaguchi ,

  * E-mail: hiroshi.kawaguchi@aist.go.jp

  Affiliations Biophysics Program, Molecular Imaging Centre, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba, Japan, Human Informatics Research Institute, National Institute of Advanced Industrial Science and Technology, Central 6, 1-1-1 Higashi, Tsukuba, Japan

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• Hitoshi Shimada,

  Affiliation Molecular Neuroimaging Program, Molecular Imaging Centre, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba, Japan

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• Fumitoshi Kodaka,

  Affiliations Molecular Neuroimaging Program, Molecular Imaging Centre, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba, Japan, Department of Psychiatry, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, Japan

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• Masayuki Suzuki,

  Affiliation Molecular Neuroimaging Program, Molecular Imaging Centre, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba, Japan

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• Hitoshi Shinotoh,

  Affiliation Molecular Neuroimaging Program, Molecular Imaging Centre, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba, Japan

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• Shigeki Hirano,

  Affiliation Molecular Neuroimaging Program, Molecular Imaging Centre, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba, Japan

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• Jeff Kershaw,

  Affiliation Biophysics Program, Molecular Imaging Centre, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba, Japan

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• Yuichi Inoue,

  Affiliation Japan Somnology Center, Neuropsychiatric Research Institute, 91, Benten-cho, Shinjuku-ku, Tokyo, Japan

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• Masaki Nakamura,

  Affiliation Japan Somnology Center, Neuropsychiatric Research Institute, 91, Benten-cho, Shinjuku-ku, Tokyo, Japan

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• Taeko Sasai,

  Affiliation Japan Somnology Center, Neuropsychiatric Research Institute, 91, Benten-cho, Shinjuku-ku, Tokyo, Japan

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• Mina Kobayashi,

  Affiliation Japan Somnology Center, Neuropsychiatric Research Institute, 91, Benten-cho, Shinjuku-ku, Tokyo, Japan

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• Tetsuya Suhara,

  Affiliation Molecular Neuroimaging Program, Molecular Imaging Centre, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba, Japan

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• Hiroshi Ito

  Affiliations Biophysics Program, Molecular Imaging Centre, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba, Japan, Advanced Clinical Research Center, Fukushima Medical University, 1 Hikariga-oka, Fukushima, Japan

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